A Review on Novel Drug Delivery Systems

Abstract

Changing from a conventional administration approach to an innovative bone can significantly improve the efficacy, safety, and patient adherence of a validated pharmacological combination. Reviving an old medication patch is possible with a Novel medication Delivery System. Innovative drug delivery systems solve the drawbacks of traditional drug administration methods, providing a new method of administering medications. A new and well-designed drug delivery system can significantly increase the ability to release a medicine at a controlled rate and at a specific place. Pharmaceutical firms are developing novel drug delivery technologies that effectively deliver medications to patients while lowering adverse affects. This composition covers the types and principles of novel medication delivery systems.The scientific requirements for novel drug delivery systems, such as solid dispersions, liposomes, microemulsions, nanoparticles, and solid lipid nanoparticles, can be satisfied by modern phytopharmaceutical research by examining pharmacokinetics, mechanisms of action, sites of action, and the required particular tablets and other products.

Introduction

The effectiveness of medicines heavily depends on their method of administration, which influences drug concentration, bioavailability, and side effects. Traditional treatments face limitations, driving the development of innovative drug delivery systems (DDS) that integrate polymer science, pharmaceutics, bioconjugate chemistry, and molecular biology. These advanced DDS aim to improve drug stability, controlled release, targeted delivery, reduced toxicity, and enhanced efficacy.

Novel Drug Delivery Systems for Herbal Medicines:
Modern DDS technologies have begun to improve the delivery and effectiveness of herbal medicines, which historically suffered from inconsistent efficacy due to outdated administration methods. Combining Ayurvedic knowledge with modern DDS like liposomes, nanoparticles, phytosomes, and solid lipid nanoparticles enhances the bioavailability and therapeutic effects of herbal drugs while minimizing side effects.

Key Features of Ideal DDS:

• Stability in vitro and in vivo

• Biochemical safety and non-immunogenicity

• Targeted, consistent, and controlled drug release

• Minimal drug leakage during transport

• Biodegradable carriers with easy removal from the body

Recent Advances and Types of DDS:
Innovations include phytosomes, liposomes, nanoparticles, microspheres, niosomes, ethosomes, dendrimers, and transdermal systems. Carrier-based DDS and transdermal delivery are common approaches. Nanoparticles improve drug stability and targeting, microspheres allow customizable release profiles, and liposomes/niosomes enhance drug encapsulation and delivery efficiency.

Applications of Novel DDS:

• Targeted drug delivery to specific organs or tumors

• Controlled and sustained release for better efficacy and patient compliance

• Personalized medicine tailored to individual patient needs

• Improved management of chronic diseases with fewer doses

• Combination therapies for complex or resistant diseases

• Delivery of gene and cell therapies by protecting and targeting therapeutic materials

Conclusion

A Novel Drug Delivery System (NDDS) combines cutting-edge methods with recently created dosage forms that work noticeably better than conventional ones. This innovative drug delivery system enhances therapeutic efficacy by decreasing toxicity, increasing bioavailability, and minimizing the necessity for frequent administration to address noncompliance. There is even greater potential for utilizing nanoparticulate drug delivery systems in the administration of vaccines, radiation therapy, antibiotics, anti-tumor therapies, proteins, gene therapy, AIDS treatment, and as vehicles to penetrate the blood-brain barrier.

References

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Copyright

Copyright © 2025 Pavan Sayaji Sagare, Nikhil Jadhav , Nitin Gawai, Vinayak Devidas Jadhav , Sudhanshu Dhananjay Kapase. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.