An Overview of Berries\' Bioactive Components

Abstract

Introduction

1. Nutritional Value of Fruits and Berries:

• Fruits, particularly berries, are rich in vitamins, minerals, carbohydrates, essential oils, and bioactive compounds (BACs).

• Berries are among the most consumed fruits globally due to their taste and health benefits.

• Common berries include strawberries, raspberries, blackberries (Rosaceae), blueberries (Ericaceae), and grapes (Vitaceae).

2. Health Benefits and Antioxidant Activity:

• Berries contain bioactive compounds like phenolics, flavonoids, tannins, and vitamin C with properties that are:

  • Antioxidant

  • Anti-inflammatory

  • Anticancer

  • Antibacterial

  • Neuroprotective

• These compounds help neutralize free radicals and protect against diseases such as cancer, cardiovascular and neurological diseases, diabetes, and inflammation.

3. Phenolic Compounds and Their Role:

• Phenolics are secondary plant metabolites derived from shikimic acid and acetic acid pathways.

• They include phenolic acids, flavonoids, tannins, and stilbenes.

• These compounds affect fruit color, taste, aroma, and astringency, and also aid in plant defense and reproduction.

• Flavonoids, especially anthocyanins in blueberries, are among the most beneficial polyphenols for human health.

4. Agro-industrial Waste as a Resource:

• Fruit processing produces large quantities of waste, rich in fiber and sugars, but also containing valuable bioactive compounds.

• These by-products could be repurposed for use in food, medicine, or as natural dyes and antioxidants.

5. Nutrient Composition of Berries:

• Berries are low in fat and calories but high in sugars, dietary fiber, and micronutrients.

  • Vitamin C: Highest in strawberries, lowest in blueberries.

  • Folate (B9) and Potassium: Found in strawberries, raspberries, and blackberries.

  • Vitamin K: High in blackberries and blueberries.

  • Vitamin E: Found in cranberries.

  • Carotenoids (e.g., beta-carotene, lutein): Present in blackberries.

  • Minerals (e.g., calcium, iron, phosphorus): Abundant in blackcurrants.

6. Phenolic Acids and Flavonoids – Structure and Activity:

• Phenolic acids are mainly benzoic and cinnamic acid derivatives.

  • Their antioxidant power depends on the number and position of hydroxyl groups.

  • Cinnamic acids, especially hydroxylated ones (like caffeic and chlorogenic acid), are generally more effective than benzoic acids.

• Flavonoids include:

  • Anthocyanins, flavonols, flavones, flavanols, flavanones, and others.

  • Their structure affects bioactivity, particularly antioxidant capacity.

• Tannins are classified as hydrolysable or condensed, with roles in both plant and human health.

Conclusion

Berry fruits are well recognized as natural functional goods due to their diverse composition of bioactive chemicals and their health-promoting characteristics, which are mostly due to their antioxidant activity.One of the most significant families of phytochemicals, phenolic compounds has both functional and health-promoting effects. Fruits are excellent sources of these compounds, and improved methodology for extracting, isolating, separating, identifying, and quantifying the full range of phenolic content in fruits is critical for understanding the health potential of different fruits as well as good sources of these compounds. The properties of distinct berry fruit species show significant variances in the types of bioactive chemicals they contain. Such changes can be seen in the content as well as the qualitative composition of those molecules. Phenolic chemicals and vitamin C are credited with the greatest health advantages. Berries have significant health advantages in both in vitro and in vivo investigations. They include powerful antioxidants that protect against inflammatory disorders, metabolic disorders, cardiovascular diseases, and can even lower the risk of cancer. They have antibacterial and neuroprotective effects as well. The interaction of berry phenolics with the microbiota is important for berry phenolic bioavailability and contributes to gut health.Berries have the potential to be used as pharmaceutical agents to treat a variety of diseases. Future clinical trials will be needed to investigate and improve the bioavailability of phenolic compounds found in berries, as well as to add to the evidence that berries active chemicals can be used as medicinal foods to treat a variety of ailments. The medications derived from these fruits, in particular, are being studied in the fight against cancer, which is today\'s most prevalent disease. People also eat them due of their distinctive colours, forms, and flavours (as in the food industry, pastry and cake, juice, liquor, tea, etc.). The number of berry fruit-related garden installations has recently expanded. These fruits are frequently shown on television and in ads. As a result, people are more influenced to berries. However, no adverse or toxic effects (i.e., chemical, haematological, or urinary effect) have been linked to the consumption of berries, berry juices, or other extracts, particularly aronia berries and aronia products, in vivo or in vitro (Kulling and Rawel, 2008), suggesting that the phenolic antioxidants found in berries are natural gifts for human health. However, the phenolic component content of berries and berry products is not always fully defined, and more research is needed to determine the therapeutic levels of various berry products for future clinical trials. Furthermore, more research is needed to fully comprehend the favourable benefits described thus far from a mechanistic standpoint. As a result, more emphasis should be placed on the establishment of well-controlled and high-quality clinical trials.

References

[1] A.D´avalos, C.G´omez-Cordov´es, and B. Bartolom´e, “Extending applicability of the oxygen radical absorbance capacity (ORACfluorescein) assay,” Journal of Agricultural and Food Chemistry, vol. 52, no. 1, pp. 48–54, 2004. [2] Adlercreutz H, Mazur W. Phyto-oestrogens andWestern diseases. Ann Med 1997; 29:95-120. aggregation: Studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J ClinNutr [3] Agullo, G.; Gamet, L.; Besson, C.; Demigné, C.; Rémésy, C. Quercetin exerts a preferential cytotoxic effect on active dividing colon carcinoma HT29 and Caco-2 cells. Cancer Lett. 1994, 87, 55–63. [4] Ashihara H. Blackwell, Oxford, pp. 208–302 (2006). and ischemic heart disease in humans. J Nutraceut Functional & Med Foods 2001; 3:67-93. antioxidante. Alimentaria, 329, 29-40. [5] Arnous, a.; makris, d.; kefalas, p. Correlation of pigment and flavanol content with antioxidant properties in selected aged regional wines from greece. Journal of food composition and analysis, v. 15, p. 655-665, 2002. [6] Aviram M, Dornfeld L, Rosenblat M, Volkova N, Kaplan M, Coleman R, Hayek T, Presser D, Fuhrman B. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet [7] Baby, B.; Antony, P.; Vijayan, R. Antioxidant and anticancer properties of berries. Crit Rev. Food SciNutr. 2018, [8] Barnes JS, Nguyen HP, Shen S, Schug KA. General method for extraction of blueberry anthocyanins and identification using high performance liquid chromatography-electrospray ionization-ion trap-time of flight-mass spectrometry. J Chromatogr A 2009; 1216(23): 4728-35. [9] Basu, A.; Kurien, B.T.; Tran, H.; Maher, J.; Schell, J.; Masek, E.; Schell, J.; Masek, E.; Barrett, J.R.; Lyons, T.J.; et al. Strawberriesdecrease circulating levels of tumor necrosis factor and lipid peroxides in obese adults with knee osteoarthritis. Food Funct. 2018,9, 6218–6226. [10] BENZIE, I. F. F.; STRAIN, J. J. The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: The FRAP assay. Analytical Biochemistry, v. 239, p. 70-76, 1996. [11] Boivin, D., Blanchette, M., Barrette, S., Moghrabi, A. and Beliveau, R. (2007) Inhibition of Cancer Cell Proliferation and Suppression of TNF Induced Activation of NFkappaB by Edible [12] Berry Juice. Anticancer Research, 27, 937-948. [13] Bravo, L. (1998). Polyphenols: chemistry, dietary sources, metabolism and nutritional significance. Nutrition Reviews, 56(11), 317-333. [14] Bravo, L. (1998). Polyphenols: chemistry, dietary sources, metabolism and nutritional significance. Nutrition Reviews, 56(11), 317-333. [15] Burdulis D, Ivanauskas L, Dirse V, Kazlauskas S, Razukas A. Study of diversity of anthocyanin composition in bilberry (VacciniummyrtillusL.) fruits. Medicina (Kaunas) 2007; 43(12): 971 7.[PMID: 18182842] by dietary polyphenolic compounds. Annual Review of Nutrition, 21, 381-406. [16] Castro, D.; Teodoro, A. Anticancer Properties of Bioactive Compounds of Berry Fruits—A Review. Br. J. Med. Med. Res. 2015, 6, 771–794. [17] Chen, T.; Yan, F.; Qian, J.; Guo, M.; Zhang, H.; Tang, X.; Chen, F.; Stoner, G.D.; Wang, X. Randomized phase II trial of lyophilized strawberries in patients with dysplastic precancerous lesions of the esophagus. Cancer Prev. Res. 2012, 5, 41–50. [18] Chua, M. T., Tung, Y. T., & Chang, S. T. (2008). An¬tioxidant activities of ethanolic extracts from the twigs of cinnamomumosmophloeum. Bioresource Technology. 1918-19225. doi.org/10.1016/j.bi¬ortech.2007.03.020 [19] Chung, K. T., Wong, T. Y., Wei, C. I., Huang, Y. W., & Lin, Y. (1998). Tannins and human health: a review. Critical Reviews in Food Science and Nutrition, 38(6), 421-464. Cie?lik E, Gr?da A, Adamus W (2006) Contents of polyphenolsin fruit and vegetables. Food Chem 94:135–142. [20] Clark, J.L.; Zahradka, P.; Taylor, C.G. Efficacy of flavonoids in the management of high blood pressure. Nutr. Rev. 2015,73, 799–822. [21] Cook, M.D.; Myers, S.D.; Gault, M.L.; Edwards, V.C.; Willems, M.E.T. Cardiovascular function during supine rest in endurancetrained males with New Zealand blackcurrant: A dose–response study. Eur. J. Appl. Physiol. 2017, 117, 247–254. [22] Cox, S. D., Jayasinghe, K. C., & Markham, J. L. (2005). Antioxidant activity in Australian native sarsaparilla (Smilax glyciphylla). Journal of ethnopharmacology, 101(1-3), 162-168. [23] Crozier A, Yokota T, Jaganath IB, Marks S, Saltmarsh M, and CliffordMN, Secondary metabolites as dietary components in plant-basedfoods and beverages, in Plant Secondary Metabolites: Occurrence,Structure and Role in the Human Diet, ed. by Crozier A, Clifford MN [24] Crozier, A., Jaganath, I.B., & Clifford, M.N. (2006) in PlantSecondary Metabolites: Occurrence, Structure and Role inthe Human Diet, A. Crozier, M.N. Clifford, & H. Ashihara (Eds), Blackwell Publishing Ltd., Hoboken, NJ, pp 1–24. [25] D’Archivio, M., Filesi, C., Di Benedetto, R., Gargiulo, R.,Giovannini, C., &Masella, R. (2007) Ann. Ist. Super. Sanità43,348–361 [26] Dai Q, Borenstein AR, Wu Y, Jackson JC, Larson EB.Fruit and vegetable juices and Alzheimer’s disease. [27] De Lacerda de Oliveira, L., Veras de Carvalho, M., &Melo, L. (2014) Rev. Ceres 61, 764–779. [28] Duffy, k. B. et al. A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiology of Aging, v. 29, p. 1680-1689, 2007. [29] Duffy, K.B., Spangler, E.L., Devan, B.D., Guo, Z., Bowker, J.L., Janas, A.M., Hagepanos, A., Minor, R.K., Decabo, R.,Mouton, P.R., Shukitt-Hale, B., Joseph, J.A. and Ingram, D.K. (2008). [30] A Blueberry-Enriched Diet Provides Cellular Protection against Oxidative Stress and Reduces a Kainate-Induced Learning Impairment in Rats. Neurobiology of Aging, 29, 1680-1689. [31] Duthie, S.J. Berry phytochemicals, genomic stability and cancer: Evidence for chemoprotection at several stages in the carcinogenic process. Mol. Nutr. Food Res. 2007, 51, 665–674. [32] Effect of diacylated anthocyanin derived from Ipomoea batatas cultivar Ayamurasaki can be achieved through the alpha-glucosidase inhibitory action. J Agric Food Chem 2002; 50:7244-8. [33] Effect of Insulin and (-)epicatechin. J PhysiolPharmacol 2001; 52:483-8. Fortschritte der ChemieorganischerNaturstoffe, 66, 1-117. [34] Francis, F. J. (1982). Analysis of anthocyanins. In P. Markakis (Ed.),Anthocyanins as food colors (pp. 181-207). New York: Academic Press. from foods in Alzheimer’s disease: Bioavailability, metabolism, and cellular and molecular mechanisms. Fruits. Journal of Agricultural and Food Chemistry, 56, 8418-8426. [35] G.J. McDougall, F. Shapiro, P. Dobson, P. Smith, A. Blake and D. Stewart, Different polyphenolic components of soft fruits inhibit_-amylase and _-glucosidase, Journal of Agricultural Food Chemistry 53 (2005), 2760–2766. [36] George A Manganariset.al. Berry antioxidants: small fruits providing large Benefits 2013. J Sci Food Agric 2014; 94: 825–833 (image) [37] Govers, C.; BerkelKasikci, M.; van der Sluis, A.A.; Mes, J.J. Review of the health effects of berries and their phytochemicals on the digestive and immune systems. Nutr. Rev. 2018, 76, 29–46. [38] Gu, C.; Howell, K.; Dunshea, F.R.; Suleria, H.A. Lc-esi-qtof/mscharacterisation of phenolic acids and flavonoids in polyphenolrichfruits and vegetables and their potential antioxidant activities. Antioxidants 2019, 8, 405. [39] Harborne, J. B. (1980). Plant phenolics. In: Bell EA, Charlwood BV, Archer B. (ed.) Secondary plant products. Berlin: Springer-Verlag, 330-402. [40] Haytowitz, D.B.; Pehrsson, P.R. USDA’s National Food and Nutrient Analysis Program (NFNAP) produces high-quality data for USDA food composition databases: Two decades of collaboration. Food Chem. 2018, 238, 134–138. [41] Heinonen MI, Ollilainen V, Linkola EK, Varo PT, Koivistoinen PE(1989) Carotenoids in Finnish foods: vegetables, fruits, andberries. J Agric Food Chem 37:655–659. [42] Henning, S.M.; Seeram, N.P.; Zhang, Y.; Li, L.; Gao, K.; Lee, R.P.;Wang, D.C.; Zerlin, A.; Karp, H.; Thames, G.; et al. Strawberryconsumption is associated with increased antioxidant capacity in serum. J. Med. Food 2010, 13, 116–122. [43] Hollman, P. C. H. (2001). Evidence for health benefits of plant phenols: local or systemic effects? Journal of the Science of Food and Agriculture, 81(9), 842-852. [44] Jeong, H.S.; Kim, S.; Hong, S.J.; Choi, S.C.; Choi, J.H.; Kim, J.H.; Park, C.Y.; Cho, J.Y.; Lee, T.B.; Kwon, J.W.; et al. Black raspberry extract increased circulating endothelial progenitor cells and improved arterial stiffness in patients with metabolic syndrome: A randomized controlled trial. J. Med. Food 2016, 19, 346–352. [45] K. Thaipong, U. Boonprakob, K. Crosby, L. Cisneros-Zevallos,and D. Hawkins Byrne, “Comparison of ABTS, DPPH, FRAP,andORACassays for estimating antioxidant activity fromguava fruit extracts,” Journal of FoodCompositionandAnalysis, vol. 19 [46] Kalt, W. and Dufour, D. (1997) Health Functionality of Blueberries. HortTechnology, 7, 216-221. [47] Khan N, Mukhtar H. Multitargeted therapy of cancer by green tea polyphenols. Cancer Lett 2008; 269:269-80. [48] KIM, D. O. et al. Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals. Journal of Agricultural and Food Chemistry, v. 50, p. 3713-3717, 2002. [49] Lien, e. J. Et al. Quantitative structure-activity relationship analysis of phenolics antioxidants. Free radical biology & medicine, v. 26, p. 285-294, 1999. [50] Kondratyuk TP, Pezzuto JM. Natural ProductPolyphenols of Relevance to Human Health. PharmBiol 2004; 42:46-63. [51] Lampe, J. W. (1999). Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies. The American Journal of Clinical Nutrition, 70,475S-490S. [52] Lattanzio, V. (2013) in Natural Products, K.G. Ramawat&J.M. Mérillon (Eds.), Springer, Berlin, Heidelberg, Germany,pp 1543–1573. [53] Lee, J., &Wrolstad, R. E. (2004). Extraction of anthocyanins andpolyphenolics from blueberry processing waste. Journal of FoodScience, 69(7), 564-573. [54] Letenneur L, Proust-Lima C, Le Gouge A, Dartigues J, Barberger-Gateau P. Flavonoid intake and cognitive decline over a 10-year period. Am J Epidemiol 2007; 165:1364-71. [55] Li, Z.X.; Ma, J.L.; Guo, Y.; Liu, W.D.; Li, M.; Zhang, L.F.; Zhang, Y.; Zhou, T.; Zhang, J.Y.; Gao, H.E.; et al. Suppression of Helicobacter pylori infection by daily cranberry intake: A double-blind, randomized, placebo-controlled trial. J. Gastroenterol. Hepatol. 2021, 36, 927–935. [56] Lu, T.; Finkel, T. Free radicals and senescence. Experimental Cell Research, v. 314, p. 1918-1922, 2008.. [57] Luís, Â.; Duarte, A.P.; Pereira, L.; Domingues, F. Interactions between the major bioactive polyphenols of berries: Effects on antioxidant properties. Eur. Food Res. Technol. 2018, 244, 175–185. [58] Manganaris, G.A., Goulas, V., Vicente, A.R. and Terry, L.A., 2014. Berry antioxidants: small fruits providing large benefits. Journal of the Science of Food and Agriculture, 94(5), pp.825-833 [59] Marhuenda, J., Alemán, M.D., Gironés-Vilaplana, A., Pérez, A., Caravaca, G., Figueroa, F., Mulero, J. and Zafrilla, P., 2016. Phenolic composition, antioxidant activity, and in vitro availability of four different berries. Journal of Chemistry, 2016 [60] Marinova D, Ribarova F (2007) HPLC determination ofcarotenoids in Bulgarian berries. J Food Compost Anal20:370–374. [61] Markus MA, Morris BJ. Resveratrol in preventionand treatment of common clinical conditions of aging. Clin Interv Aging 2008; 3:331-9. [62] Mateos, R.; Bravo, L. Chromatographic and electrophoretic methods for the analysis of biomarkers of oxidative damage to macromolecules (DNA, lipids, and proteins). Journal of the Serbian Chemical Society, v. 30, p. 175-191, 2007 [63] Matsui T, Ebuchi S, Kobayashi M, Fukui K, Sugita K, Terahara N, Matsumoto K. Anti-hyperglycemic [64] Molan, A.L.; Lila, M.A.; Mawson, J.; De, S. In vitro and in vivo evaluation of the prebiotic activity of water-soluble blueberry extracts. World J. Microbiol. Biotechnol. 2009, 25, 1243–1249. [65] Naidu KA (2003) Vitamin C in human health and disease is stilla mystery. An overview Nutr J 2:7. [66] Nardini M, Natella F, Scaccini C. Role of dietary polyphenols in platelet aggregation. A review of the no. 6-7, pp. 669–675, 2006. [67] Okuda, T., Yoshida, T., &Hatano, T. (1995). Hidrolyzable tannins and related polyphenols. [68] Ozcan, T., Akpinar-Bayizit, A., Yilmaz-Ersan, L., &Delikanli, B. (2014) Int. J. Chem. Eng. Appl. 5, 393–396.doi:10.7763/IJCEA.2014.V5.416 [69] Patel N et al. (2021) , Study of potential compounds of fresh and dried berries and comparative analysis of their phenolic, flavonoid content, antioxidant and antimicrobial properties ,Journal of Emerging Technologies and Innovative Research Vol 8, Issue 6 ,528-535 [70] Paturi, G.; Mandimika, T.; Butts, C.A.; Zhu, S.; Roy, N.C.; McNabb,W.C.; Ansell, J. Influence of dietary blueberry and broccoli on cecal microbiota activity and colon morphology in mice, a model of inflammatory bowel diseases. Nutrition 2012, 28, 324–330 [71] Pellegrini, N., Serafini, M., Colombi, B., Del, D., Sal¬vatore S., Bianchi, M., &Brighenti, F. (2003). Total antioxidant capacity of plant foods, beverages and oils consumed in Italy assessed by three different in vitro assays. J Nutr, 133: 2812–2819p [72] Percival, M. (1998). Antioxidants. Clinical Nutrition Insights, 10, 1-4. [73] Prior, R.L.;Wilkes, S.; Rogers, T.; Khanal, R.C.; Wu, X.; Howard, L.R. Purified blueberry anthocyanins and blueberry juice alterdevelopment of obesity in mice fed an obesogenic high-fat diet. J. Agric. Food Chem. 2010, 58, 3970–3976. [74] Puupponen-Pimiä R, Nohynek L, Alakomi H-L, Oksman-Caldentey K-M (2005) Bioactive berry compounds—noveltools against human pathogens. ApplMicrobiolBiotechnol 67:8–18. [75] Ragan, M. A., &Glombitza, K. (1986). Phlorotannin: Brown algal polyphenols. Progress in Physiological Research, 4, 177-241. [76] Razungles A, Oszmia?ski J, Sapis J-C (1989) Determination ofcarotenoids in fruits of Rosa sp. (Rosa canina and Rosa rugosa)and of chokeberry (Aroniamelanocarpa). J Food Sci 54:774–775. [77] RE, R. et al. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology & Medicine, v. 26, p. 1231-1237, 1999. [78] Reis-Giada, M.d.L. (2014) in Oxidative Stress and ChronicDegenerative Diseases: A Role for Antioxidants, J.A. Morales-Gonzalez (Ed.), IntechOpen Ltd, London, United Kingdom, pp 87–112. [79] Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 1992; 339:1523-6. [80] Rizvi S I, Zaid M A. Insulin like effect of epica techin on membrane acetylcholinesterase activity in type 2. [81] Rizvi SI, Zaid MA, Anis R, Mishra N. Protective role of tea catechins against oxidation-induced damage of type 2 diabetic erythrocytes. Clin Exp Pharmacol Physiol 2005; 32:70-5. [82] Rizvi SI, Zaid MA. Impairment of sodium pump and Na/H exchanger in erythrocytes from non-insulin. [83] Rizvi SI, Zaid MA. Intracellular reduced glutathione content in normal and type 2 diabetic erythrocytes: [84] Romandini, S.; Mazzoni, L.; Giampieri, F.; Tulipani, S.; Gasparrini, M.; Forbes-Hernandez, T.Y.; Locorotondo, N.; D’Alessandro, M.; Mezzetti, B.; Bompadre, S.; et al. Effects of an acute strawberry (Fragaria _ ananassa) consumption on the plasma antioxidant status of healthy subjects. J. Berry Res. 2013, 3, 169–179. [85] Rufino, M. S. M., Alves, R. E., de Brito, E. S., Pérez-Jiménez, J., Saura-Calixto, F., & Mancini-Filho, J. (2010). Bioactive compounds and antioxidant capacities of 18 non-traditional tropical fruits from Brazil. Food Chemistry, 121(4), 996-1002. [86] Scalbert A, Manach C, Morand C, Remesy C. Dietary polyphenols and the prevention of diseases. Crit Rev Food SciNutr 2005; 45:287-306. [87] Scalbert, A, & Williamson, G. (2000). Dietary intake and bioavailability of polyphenols. Journal of nutrition, 130, 2073S-2085S. [88] Scarmeas N, Luchsinger J A, Mayeux R, Stern Y. Mediterranean diet and Alzheimer disease mortality. Neurology 2007; 69: 1084-93. [89] Seeram, N. P. (2008). Berry fruits: compositional elements, biochemical activities, and the impact of their intake on human health, performance, and disease. Journal of Agricultural and Food Chemistry, 56(3), 627-629. [90] Seeram, N.P., Adams, L.S., Zhang, Y., Sand, D. and Heber, D. (2006) Blackberry, Black Raspberry, Blueberry, Cranberry,Red Raspberry and Strawberry Extracts Inhibit Growth and Stimulate Apoptosis of Human Cancer Cells in Vitro.Journal of Agricultural and Food Chemistry, 54, 9329-9339. [91] Sellappan, S., Akoh, C. C., &Krewer, G. (2002). Phenolic compounds and antioxidant capacity of Georgia-grown blueberries and blackberries. Journal of Agricultural and Food Chemistry, 50(8), [92] Seymour, E.M.; Tanone, I.I.; Urcuyo-Llanes, D.E.; Lewis, S.K.; Kirakosyan, A.; Kondoleon, M.G.; Kaufman, P.B.; Bolling, S.F.Blueberry intake alters skeletal muscle and adipose tissue peroxisome proliferator-activated receptor activity and reduces insulinresistance in obese rats. J. Med. Food 2011, 14, 1511–1518. [93] Shahidi F, Naczk M (2004) Phenolic compounds in fruits andvegetables. In: Phenolics in food and nutraceutical, CRC LLC,pp 131–156 [94] Shi, N.; Clinton, S.K.; Liu, Z.; Wang, Y.; Riedl, K.M.; Schwartz, S.J.; Zhang, X.; Pan, Z.; Chen, T. Strawberry phytochemicals inhibit azoxymethane/dextran sodium sulfate-induced colorectal carcinogenesis in Crj: CD-1 mice. Nutrients 2015, 7, 1696–1715. [95] Singleton, V. L.; Rossi, J. A. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American journal of enology and viticulture, v. 16, p. 144-158, 1965. [96] Siracusa, L.; Ruberto, G. Not only what is food is good—Polyphenols from edible and nonedible vegetable waste. In Polyphenols in Plants; Elsevier: Amsterdam, The Netherlands, 2019; pp. 3–21. [97] Skrovankova, S., Sumczynski, D., Mlcek, J., Jurikova, T., &Sochor, J. (2015). Bioactive compounds and antioxidant activity in different types of berries. International journal of molecular sciences, 16(10), 24673-24706. [98] Skrovankova, S.; Sumczynski, D.; Mlcek, J.; Jurikova, T.; Sochor, J. Bioactive compounds and antioxidant activity in different types of berries. Int. J. Mol. Sci. 2015, 16, 24673–24706. [99] Sokó?-??towska, A., Oszmia?ski, J., &Wojdy?o, A. (2007). Antioxidant activity of the phenolic com¬pounds of hawthorn, pine and skullcap. Food chemistry, 103(3), 853-859. [100] Somasagara, R.R.; Hegde, M.; Chiruvella, K.K.; Musini, A.; Choudhary, B.; Raghavan, S.C. Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice. [101] Song, Y.; Park, H.J.; Kang, S.N.; Jang, S.H.; Lee, S.J.; Ko, Y.G.; Kim, G.S.; Cho, J.H. Blueberry peel extracts inhibit adipogenesis in3T3-L1 cells and reduce high-fat diet-induced obesity [102] Sosa, V.; Moline, T.; Somoza, R.; Paciucci, R.; Kondoh, H.; LLeonart, M.E. Oxidative stress and cancer: An overview. Ageing Res. Rev. 2013, 12, 376–390. [103] Stoner, G.D.; Seeram, N.P. Berries and Cancer Prevention; Springer: Berlin/Heidelberg, Germany, 2011. [104] Stratil, P., Klejdus, B., &Kubá?, V. (2007). Determina¬tion of phenolic compounds and their antioxidant ac¬tivity in fruits and cereals. Talanta, 71(4), 1741-1751. [105] Talalay P, De Long MJ, Prochaska HJ. Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis. Proc Natl Acad Sci USA 1988; 85:8261- 5. the Kame Project. Am J Med 2006; 119: 751-9. [106] Tomás-Barberán, F. A., &Espín, J. C. (2001). Phenolic compounds and related enzymes as determinants of quality in fruits and vegetables. Journal of the Science of Food and Agriculture, 81(9), 853-876. [107] Tsuda, T.; Horio, F.; Uchida, K.; Aoki, H.; Osawa, T. Dietary cyanidin 3-O-_-D-glucoside-rich purple corn color prevents obesityand ameliorates hyperglycemia in mice. J. Nutr. 2003, 133, 2125–2130 [108] Tulipani, S.; Mezzetti, B.; Capocasa, F.; Bompadre, S.; Beekwilder, J.; de Vos, C.H.; Capanoglu, E.; Bovy, A.; Battino, M. Antioxidants, phenolic compounds, and nutritional quality of different strawberry genotypes. J. Agric. Food Chem. 2008, 56, 696–704. [109] Vendrame, S.; Klimis-Zacas, D. Potential factors influencing the effects of anthocyanins on blood pressure regulation in humans: A review. Nutrients 2019, 11, 1431. [110] Vieira, D.R.; Amaral, F.M.; Maciel, M.C.; Nascimento, F.R.; Libério, S.A.; Rodrigues, V.P. Plant species used in dental diseases: Ethno pharmacology aspects and antimicrobial activity evaluation. J. Ethnopharmacol. 2014, 155, 1441–1449. [111] Vita JA. Polyphenols and cardiovascular disease: effects on endothelial and platelet function. Am J Vladimir-Kneževi?, S., Blažekovi?, B., Štefan, M.B., & Babac, M. (2012) in Phytochemicals as Nutraceuticals: Global Approaches to Their Role in Nutrition and Health, V. Rao(Ed.), Intech Open Ltd, London, United Kingdom, pp 150–180. [112] Whyte, A.R.; Cheng, N.; Fromentin, E.; Williams, C.M. A randomized, double-blinded, placebo-controlled study to compare the safety and efficacy of low dose enhanced wild blueberry powder and wild blueberry extract (ThinkBlue™) in maintenance of episodic and working memory in older adults. Nutrients 2018, 10, 660. [113] Wolfe, K.L., Kang, X., He, X., Dong, M., Zhang, Q. and Liu, R.H. (2008) Cellular Antioxidant Activity of Common [114] WU, X. et al. Lipophilic and hydrophilic antioxidant capacities of common foods in the united states. Journal of Agricultural of Food Chemistry, v. 52, p. 4026-4037, 2004. [115] Yang, C. S., Landau, J. M., Huang, M. T., & Newmark, H. L. (2001). Inhibition of carcinogenesis by dietary polyphenolic compounds. Annual Review of Nutrition, 21, 381-406. [116] Yang, C. S., Landau, J. M., Huang, M. T., & Newmark, H. L. (2001). Inhibition of carcinogenesis by dietary polyphenolic compounds. Annual Review of Nutrition, 21, 381-406. [117] Yang, J.; Cui, J.; Chen, J.; Yao, J.; Hao, Y.; Fan, Y.; Liu, Y. Evaluation of physicochemical properties in three raspberries (rubusidaeus) at five ripening stages in northern china. Sci. Hortic. 2020, 263. [118] Yen, C.H.; Chiu, H.F.; Huang, S.Y.; Lu, Y.Y.; Han, Y.C.; Shen, Y.C.; Venkatakrishnan, K.;Wang, C.K. Beneficial effect of Burdock complex on asymptomatic Helicobacter pylori-infected subjects: A randomized, double-blind placebo-controlled clinical trial. Helicobacter 2018, 23, e12469. [119] Zhang, Y.; Seeram, N.P.; Lee, R.; Feng, L.; Heber, D. Isolation and identification of strawberry phenolics with antioxidant and Zhu, Y.; Sun, J.; Lu, W.; Wang, X.; Han, Z.; Qiu, C. Effects of blueberry supplementation on blood pressure: A systematic review and meta-analysis of randomized clinical trials. J. Hum. Hypertens. 2017, 31, 165–171. [120] Zunino, S.J.; Parelman, M.A.; Freytag, T.L.; Stephensen, C.B.; Kelley, D.S.; Mackey, B.E.; Woodhouse, L.R.; Bonnel, E.L. Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects. Br. J. Nutr. 2012,108, 900–909.

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