Bio-Electronic Medicine

Abstract

Bioelectronic medicine is dedicated to exploring and influencing the electrical activity in the neural system to develop new treatment approaches [1].Integrating insights from microelectronics, materials science, IT, neurology, and medicine, BEM offers innovative solutions that address unfulfilled clinical needs and revolutionize therapeutic approaches [2].Bioelectronic medicine offers transformative potential for diagnosing and treating a wide range of conditions, including cancer, diabetes, neurodegenerative diseases, and more[1].Bioelectronic medicine is based on mechanistic evidence that neural signals influence physiological and pathological processes, as well as improvements in tissue-device interfaces and signal processing[3].BEM has been useful for mobility problems and the enhancement of prosthetic devices[4].

Introduction

Bioelectronic medicine (BEM) explores innovative treatments for conditions like movement disorders and inflammatory diseases by modulating peripheral nerves, which influence various physiological functions. This interdisciplinary field addresses ethical, societal, regulatory, and patient-related issues while developing customized neuro-modulation technologies tailored to specific diseases and patient groups. Advances in neuro-reflex mapping at the molecular level and improved interfaces are enhancing monitoring and treatment capabilities.

The literature emphasizes decoding neurological pathways for organ control, developing precise neuromodulation devices, and accelerating clinical adoption by easing regulatory hurdles. BEM offers cost-effective alternatives or complements to traditional drugs with fewer side effects, rooted in a history of bioelectricity research dating back to Galvani’s work.

Methodologically, BEM targets diverse conditions such as paralysis, diabetes, and autoimmune diseases using small, implantable devices that monitor and adjust nerve signals in closed-loop systems. Innovations like the ElectRx program focus on peripheral nervous system therapies. Biomedical technology advances enable large-scale biosignal data collection and processing, incorporating AI tools for real-time analysis and therapeutic feedback.

Results demonstrate effective real-time biosignal acquisition, accurate AI-based analysis, rapid therapeutic control, and successful remote monitoring, with future work aiming to improve system robustness and reduce reliance on cloud infrastructure.

Conclusion

Bioelectronic medicine (BEM) opens up fresh possibilities for addressing conditions such as movement disorders and treatment-resistant inflammatory diseases [4].Bioelectronic medicine encompasses ethics, societal impact, regulatory concerns, reimbursement policies, and patient viewpoints, encouraging collaboration across multiple disciplines[1].Activating or suppressing peripheral nerves can have an impact on a wide range of physiological processes [5].

References

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Copyright

Copyright © 2025 T Karan Sai, Sriganesh V. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.