Exploring the Anti-inflammatory and Antioxidant Activities of Ethanolic Flower Extracts of Volkameria inermis

Abstract

The Research work describes the preparation and evaluation of ethanolic flower extracts from volkameria inermis, a plant recognized for its bioactive components together with flavonoids, steroids, terpenes, alkaloids, saponins, and phenolic compounds. The goal of the research work is to create a plant-primarily based remedy for inflammation. The floral extract was prepared by way of the Soxhlet method and subjected to preliminary phytochemical screening and Active compounds have been characterized with the aid of Spectroscopic Methods. The extract\'s antioxidant and anti-inflammatory activities were assessed in vitro and vivo. Results indicated significant antioxidant and anti-inflammatory activities. The discovery promotes Volkameria inermis as a feasible natural opportunity for artificial anti-inflammatory medications, with the gain as fewer aspect outcomes.

Introduction

Inflammation is a natural defense response against infection or injury but is linked to several diseases such as cancer, heart disease, and arthritis. It is closely related to oxidative stress, where free radicals promote inflammation. Antioxidants can reduce inflammation by neutralizing free radicals. Synthetic anti-inflammatory drugs, while effective, often cause adverse effects, driving interest in natural alternatives.

The plant Volkameria inermis, known for various bioactive compounds (e.g., flavonoids, alkaloids, glycosides), traditionally used for medicinal purposes, was studied for its antioxidant and anti-inflammatory potential. The study involved collecting and preparing ethanolic extracts from its flowers, followed by phytochemical screening, chromatographic separation, and spectroscopic characterization (FTIR).

Antioxidant Activity:
Tested via DPPH and phosphomolybdenum assays, the extract showed strong, dose-dependent free radical scavenging ability, with inhibition rates close to the standard antioxidant ascorbic acid.

Anti-Inflammatory Activity:
Assessed using in vitro methods (HRBC membrane stabilization and protein denaturation) and an in vivo carrageenan-induced paw edema model in mice, the extract demonstrated significant anti-inflammatory effects comparable to the standard drug diclofenac sodium, inhibiting protein denaturation and reducing inflammation in a dose-dependent manner.

The findings suggest that Volkameria inermis flower extract has potent antioxidant and anti-inflammatory properties, supporting its potential as a natural therapeutic agent for inflammatory conditions linked to cancer, arthritis, and cardiovascular diseases.

Conclusion

According to the findings of this study, Ethanolic flower extract of Volkameria inermis has powerful antioxidant, anti-inflammatory properties, which are attributed to the presence of phenolics and flavonoids, Steroids, alkaloids. A possible source of natural pharmacological compounds that could aid in slowing the progression of a number of chronic illnesses is also suggested by these studies. However, more research is required to isolate and identify bioactive chemicals and assess them in vivo models in order to pinpoint their precise mode of action as anti-inflammatory and antioxidant agents.

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Copyright

Copyright © 2025 Vaidehi B.N.B., Manasa G, Sirisha D, Vyshanavi E.D.N., Sandhya D., Dayakar CH, Malasree Gandham. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.