Formulation and Evaluation of Antimicrobial Polyherbal Dusting Powder

Abstract

The work\'s main objective were to formulate and analyze an antimicrobial polyherbal dusted powder. The sprinkling powder was produced for this particular research. Every one of the elements have been mixed in a mortar and pestle to generate the dusting powder. Physical features (color, odor, grittiness, while appearance), solubility, Ph, along with micromeritic attributes (particle dimension, extent of surface, density (bulk, tapped), angle of repose, Carr\'s index, Hausner\'s ratio, alongside volume (bulk, tapped) had all been analyzed for the prepared dusting powder. The effectiveness of antibiotics against microorganisms such as Staphylococcus aureus and Escherichia coli was studied. The microbiological the experiment carried out utilising the well-adapted diffuser cupping screen method utilizing a mix of cultures from the two microorganisms stated above. The infectiousness produced by several microorganisms were used to test these antibacterial agents. These microorganisms were cultivated in nutrient-rich media designed to be appropriate for their development. One gram of powder had to dissolve in the ten milliliters of water for generating the sample. After being autoclave sterilized, the sample was next transferred to the hard agar environment. Before a component of each of the plates had been streaked with a culture of bacteria and refrigerated for 48 hours at 370C to give the cultures to expand. Throughout the time of incubation, observations were made of the organisms\' growth and the zone of inhibition that surrounding the mixture being used. This was found when the formulation functioned very effectively towards microbiology. populations. The aromatic oils showed highly effective versus S. aureus and E. coli, and additional microbes. We reach an inference that the polyherbal dusting powder formulation exhibited antibacterial action and should be evaluated for the treatment of a number of topical dermatological disorders.[1]

Introduction

Pressure Ulcers (Bedsores):
Pressure ulcers develop from prolonged pressure on the skin, especially in bedridden patients, causing tissue damage and necrosis. Common sites include heels, elbows, and the tailbone. They are caused by pressure, shear, friction, and moisture. Bedsores are classified into four stages, ranging from non-blanchable redness (Stage I) to full-thickness tissue loss with possible muscle and bone damage (Stage IV). Treatment involves pressure relief, cleaning, dressings, antibiotics, nutrition, and possibly surgery.

Dusting Powder:
Dusting powders are finely ground substances applied to wounds or skin to absorb moisture, reduce irritation, and provide a cooling effect. They are used for burns, wounds, and surgical sites.

Types:

• Medical powders for superficial skin conditions, must be sterilized and pathogen-free.

• Surgical powders for burns and severe wounds, also sterilized.

Properties:
Should maintain consistency, absorb moisture, spread easily, adhere to skin, and prevent drainage.

Advantages:
Easy to carry, chemically stable, affordable, suitable for all ages, and easy to apply.

Disadvantages:
Some powders can decompose easily or are unstable in air and may cause physiological fragility.

Objectives:
To evaluate natural remedies in wound healing, improve patient outcomes, ensure safety, and study dusting powders.

Mixing Methods:
Include mechanical mixing, manual mixing (triturating, swirling, slapping), with equipment varying by scale (spatula, mortar and pestle, large-scale mixers).

Packaging:
Dusting powders are packaged in shaker containers or sealed jars to protect from moisture and light. Double-wrapping is used for moisture-sensitive drugs.

Key Ingredients:

• Starch: Absorbent base

• Talc: Absorbent and soothing mineral

• Kaolin: Moisture replenisher and anti-inflammatory

• Zinc stearate: Lubricant and stabilizer

• Clove oil: Antibacterial and anti-inflammatory

• Rose oil: Aromatic with health benefits

Preparation Procedure:
Ingredients are measured, ground, sieved, sterilized, mixed, cooled, and packed with proper labeling.

Evaluation Tests:
Include physical characteristics, pH, particle size, density measurements, flow properties (angle of repose, Carr’s index, Hausner ratio), moisture content, and antimicrobial activity against bacteria and fungi.

Conclusion

The purpose of the study aimed to generate a thin layer of powder comprised combined talc, carbohydrates, kaolin, zinc stearate, rose oil, with clove oil. It came to light that the antifungal that polyherbal dusting powder formulation conformed with all particle properties while generating positive outcomes. Good antimicrobial activity against E. coil, S. aureus, and Candida has been demonstrated during the evaluation study. [3]

References

[1] S.P. Karande*1, Y.U. Rahangdale1, H.S. Kanhere1, S.K. Rathod1, S.Y. Dhabale2, Formulation of antimicrobial polyherbal dusting powder and its evaluation, International Journal for Pharmaceutical Research Scholars (IJPRS) V-9, I-4, 2020 ISSN: 2277 - 7873 RESEARCH ARTICLE © Copyright reserved by IJPRS 1 [2] Sunita N Surse*, Shweta I Sonawane, Priyanka P Sananse, Rani S Kankate, Moreshwar P Patil, Sanjay J Kshirsagar, Wound Healing Potential of Polyherbal Dusting Powder for the Treatment of Bedsores, Received: 07th August, 2023; Revised: 06th October, 2023; Accepted: 09th October, 2023; Available Online: 25th December, 2023 [3] Mr. Abhang Omkar Rajkumar1, Mr. Gaikwad T.A.2, Formulation and Evaluation of Herbal Dusting Powder, International Journal of Research Publication and Reviews Journal homepage: www.ijrpr.com ISSN 2582-7421 [4] Manesh B. Gunjal , Dr. Rajendra M. Kawade , Santosh D. Kande, FORMULATION OF ANTIFUGAL & ANTIMICROBIAL POLYHERBAL DUSTING POWDER FROM ARGEMONE MEXICANA L AND ITS EVALUTION,IJCRT,ISSN: 2320-2882

Copyright

Copyright © 2025 Mr. Devang Shelke, Ms. Pooja Gaikwad, Mr. Nitin Gawai, Ms. Nikita Kolape, Mr. Swaraj Tamhane. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.