Formulation and Evaluation of Herbal Antifungal Cream

Abstract

Fungal diseases become a major medical problem. Fungal disease is difficult to manage because they tend to be chronic, hard to diagnosis. The fungal infection is a common condition caused by fungi. The herbal antifungal cream was formulated by using various herbs such as neem and aloe vera. Herbal medicine is one of the oldest and most universal system of health care system. The herbal antifungal cream is very helpful and it is fewer side effects. All herbal ingredients are easily available in market. The herbal antifungal cream is used to treat fungal infection which most commonly affect our skin, hair and nails. Herbal antifungal cream are used to treat fungal skin infection such as athletes foot, ringworm and jock itch. This herbal antifungal cream represents a natural and safe to use, and this herbal antifungal cream is beneficial in reduction of fungal infection.

Introduction

Overview:
Fungal skin infections like athlete's foot, ringworm, and jock itch are widespread and commonly caused by dermatophytes, yeasts, or molds. Conventional antifungal treatments (topical/oral) can have side effects and are facing growing resistance from fungal pathogens. As a response, there is increased interest in herbal remedies due to their natural antifungal, antimicrobial, and anti-inflammatory properties.

Common Fungal Infections Discussed:
Athlete's Foot (Tinea Pedis):
Affects skin between toes; causes redness, cracking, itching, and scaling.

Ringworm:
Circular rash on arms, legs, or scalp; red or silver with a clear center and raised edge.

Jock Itch (Tinea Cruris):
Appears in groin, thighs, and buttocks; itchy, red, ring-shaped rash.

Herbal Alternatives:
Plants like Neem, Turmeric, Aloe Vera, Garlic, and Catharanthus roseus contain bioactive compounds such as terpenoids, flavonoids, and alkaloids, known for strong antifungal activity. These ingredients offer a safer, natural alternative to chemical treatments.

Formulation of Herbal Antifungal Cream:
The cream is developed using natural extracts and cosmetic-safe additives.

It provides topical treatment for fungal infections with minimal side effects.

Key Ingredients:
Ingredient    Role/Function
Catharanthus roseus    Antifungal, healing agent
Neem extract    Antibacterial, antifungal
Turmeric extract    Anti-inflammatory, antiseptic
Aloe vera gel    Soothing, skin healing
Glycerine    Moisturizer
Beeswax, Borax, Bentonite    Cream base and stabilizers
Methyl paraben    Preservative
Rose oil    Fragrance, mood-enhancing, antimicrobial
Tween-20    Emulsifier for smooth texture
Silica gel    Moisture control

Methodology:
Collection of herbal materials.

Extraction of active compounds.

Cream Preparation using standard formulation methods.

Evaluation via tests like pH check, patch testing, spreadability, and viscosity assessment.

Conclusion

The increasing global awareness Of the environmental impact Of pharmaceuticals and a growing desire for sustainable, natural solutions have propelled herbal remedies into the spotlight. Herbal antifungal creams, harnessing the power Of plant extract, represent a compelling alternative to synthetic medications, offering a balance between efficacy and safety-one ofthe key strengths lies in the generally well-tolerated nature ofherbal formulation, Often associated with synthetic counterparts. Scientific advancements in herbal medicine research further substantiate the efficacy Of specific plant compounds against fungal pathogens. This intersection Of traditional herbal knowledge and modern scientific validation enhances the credibility Of herbal antifungal remedies, paving the way for great integration into mainstream health care practices. The future trajectory Of herbal antifungal creams is marked by sustainability, safety and efficacy making them a compelling choice in the evolving landscape Of antifungal treatments.?

References

[1] Jincy V Varghese., et al. \"A Review on Formulation AndevaluationOfPolyherbal antifungal Cream\". International Journal Of Creative Research Thoughts (Ijcrt) 10.4 (2022). [2] Nisha Devi., et al. \"A review on Herbal Cosmetics\". World Journal Of Pharmaceutical Research 7.08 (2022): 298-310. [3] Arati D Powar and Dr. Sachin A. \"NitavePolyherbal Antifungal Cream\". World Journal of Pharmaceutical Research 11.5 (2022): 904-920. [4] MohitSolanki., et al. \'Formulation and evaluation Of antifungal cream using NelumboNucifera and azadirachtainmdica\". Bulletin Of Pharmaceutical Research9.13 (2019): 167. [5] Nikhil NitinNavindgikar., et al. \'formulation And Evaluation Of MultipurposeHerbal Cream\". International Journal Of Current Pharmaceutical Research 12.3 [6] AmolPimpale. \"Formulation and evaluation Of antibacterial, antifungal cream Of garlic Oil\". International Journal of Trend in Research and Development 3.1 (2018). [7] Sheraz Khan Azher., et al. \"Formulation And Evaluation Of Herbal Anti Bacterial, Anti Fungal Cream\". International Journal Of Pharmaceutical Research and Applications 8.3 (2023): [8] .Veena S., et al. \"Formulation and Evaluation Of Antifungal Cream OfChlorphenesin\". International Journal Of current Pharmaceutical Research 13.5 (2021). [9] KumbharAbhishekSomanath., et al. \'TreprationAnd Evaluation Of Herbal Anti Fungal Cream\". International Journal Of Creative Research Thoughts (Ijcn) 9.12 (2021). [10] MarcinRozewicz and Marta Wyzinska. \'The most important fungal diseases Of cereals- problems and possible solution\". Agronomy I I (2021): 714. [11] Jason E Stajich and Mary L Berbee. \'The fungi\". Current Biology 19.18 (2018):R840. [12] Peter C I-wel and IshworThapa. \"Review Of methods for identification OfZygomycota\". Labmedicine 42.5 (2011). [13] Cristian J Zambrano., et al. \"Diversity and distribution Of macro fungi (Ascomycota)\". Biodiversity Data Journal I I (2023): e 104307. [14] G Kiran Kumar Reddy and AlwarRamanujamPadmawati. \"Fungal infections:pathogenesis, anti fungal and alternate treatment approaches\". Current Research in Microbial Sciences3 (2022): 100137. [15] KusumKaushik and ShwetaAgarwal. \'Role Of herbal antifungal agents for the management Of fungal diseases\". Asian Journal Of Pharmaceutical and Clinical Research 12.7 (2019). [16] Ramdas B Darade and Krushna K Zambare. \"An overview on pharmacotherapy Of jock itch\". World Journal ofPharmaceutical Research 9.1 (2019): 851-856. [17] Denning DW, Hope WW. Therapy for fungal diseases:opportunities and priorities.Trends in [18] Lim SMS, Sinnollareddy M, Sime FB. Challenges inantifungal therapy in diabetes mellitus. Journal Medicine. [19] Jamadar MJ, Shaikh RH. Preparation and evaluation otherbal gel formulation. Journal OfPharmaceuticalResearch& Education. 2017;1 (2):201-224. [20] Khandelwal KR. Practical PharmacognosyTechniquesand Experiments. 9th Ed.Pune: NiraliPrakashan; c2002,149-160. [21] Sahu RK, Roy A, Kushwah P, Sahu A. Formulation anddevelopment Of face cream containing natural products.Research Journal Of Topical and Cosmetic [22] Goyal S, Sharma P, Ramchandani V, ShrivastavaSK,Dubey PK. Novel antiinflammatory topical herbal gelscontainingWithaniasomnifera and Boswelliaserrata.lnternational Journal Of Pharmaceutical and BiologicalArchives. [23] Mishra US, Murthy PN, Mishra D, Sahu K. Formulationand standardization Of herbal gel containing methanolicextract Of Calophylluminophyllum. Asian Journal offharmaceutical and Clinical Research. 2011 [24] Dixit G, Misal G, Gulkari V, Upadhye K. Formulationand evaluation Ofpolyherbal gel for anti-inflammatoryactivity. International Journal Of PharmaceuticalSciencesand Research. 2013;4(3):1186-119 [25] Mishra US, Murthy PN, Pasa G, Nayak RK. Formulationand evaluation Of herbal gel containing methanolicextract Of Ziziphusxylopyrus. International Journal0tBiomedical and Pharmaceutical Research. 2011 ; [26] Balouiri M, Sadiki M, Ibnsouda SK. Antimicrobialactivity testing methods. Chemist Notes. Availablefrom: https://chemistnotes.com/biochemistry/antimicrobialactivity-by-agar-welldiffusion/. [27] Alderman DJ, Smith P. Development Of draft protocolsof standard reference methods for antimicrobial agentsusceptibility testing Of bacteria associated with fishdiseases. Aquaculture. [28] Anonymous. Antimicrobial susceptibility testing: asystem for standardisation.Becton Dickinson andCompany, Hong Kong; c 1986. [29] Bailey WR, Scott EG. Diagnostic Microbiology. 2nd ed-Japan: Toppan CompanyLtd.; el 966, 257-270.31. Finegold SM,

Copyright

Copyright © 2025 Bhakti Rajabhau Borade, Prof. Manoj Shere, Prathamesh Mahadev Bichewar, Raj Ramchandra Shelke , Sai Asaram Sakhare, Neha Vishnu Wanare. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.