Infrazygomatic crest (IZC) bone screws have gained widespread acceptance as an extra-alveolar skeletal anchorage system in orthodontics. Their strategic placement in the dense cortical bone of the infrazygomatic region allows clinicians to perform complex orthodontic movements with minimal reliance on dental anchorage or patient compliance. IZC bone screws are particularly advantageous for maxillary distalization, intrusion mechanics, and vertical control in patients with skeletal discrepancies. This review comprehensively discusses the anatomical considerations, screw design, biomechanical principles, clinical indications, placement protocols, success rates, complications, comparative advantages, and future perspectives of IZC bone screws, supported by current scientific evidence.
Introduction
Anchorage control is essential in orthodontic treatment, and the introduction of temporary anchorage devices (TADs) has significantly improved treatment efficiency by providing stable anchorage independent of patient compliance. Infrazygomatic crest (IZC) bone screws represent an important advancement among TADs due to their extra-radicular placement, which avoids root interference, allows higher orthodontic forces, and enables more versatile tooth movement.
The infrazygomatic crest offers dense cortical bone suitable for stable screw placement, typically 12–17 mm above the maxillary occlusal plane. Although proximity to the maxillary sinus is a concern, limited sinus penetration does not significantly affect success when adequate cortical engagement is achieved. IZC bone screws are commonly made of titanium alloy or stainless steel, with design features such as increased length, appropriate diameter, and self-drilling threads contributing to primary stability.
Biomechanically, IZC screws rely on mechanical retention rather than osseointegration. Oblique insertion angles enhance cortical contact and reduce stress, while the extra-alveolar position permits force application closer to the center of resistance, improving bodily tooth movement and minimizing unwanted effects.
Clinically, IZC bone screws are widely used for maxillary arch distalization, vertical control through posterior intrusion, and anchorage in complex orthodontic mechanics. Their use can reduce the need for extractions and improve facial esthetics. CBCT imaging and digital planning have improved placement accuracy and safety.
Reported success rates range from 75% to 95%, with failures mainly associated with poor oral hygiene, inflammation, and inadequate cortical engagement rather than patient age or minor sinus perforation. Compared to interradicular miniscrews, IZC screws provide greater freedom of movement but require advanced anatomical knowledge and precise technique. Future developments are expected to focus on AI-assisted planning, customized screw designs, and standardized clinical protocols.
Conclusion
Infrazygomatic crest bone screws provide a reliable, versatile, and efficient skeletal anchorage system in orthodontics. Their ability to support complex orthodontic mechanics with high success rates makes them a valuable tool in contemporary practice. Proper case selection, imaging, and biomechanical planning are essential for achieving predictable outcomes.
References
[1] Papadopoulos MA, Tarawneh F. The use of miniscrew implants for temporary skeletal anchorage in orthodontics: A comprehensive review. American Journal of Orthodontics and Dentofacial Orthopedics. 2007;131(4 Suppl):S52–S58.
[2] Park HS, Jeong SH, Kwon OW. Factors affecting the clinical success of screw implants used as orthodontic anchorage. World Journal of Orthodontics. 2007;8(2):151–161.
[3] Ghosh A, Nanda RS. Infrazygomatic crest anchorage: Biomechanical and clinical considerations. Journal of Indian Orthodontic Society. 2018;52(3):127–141.
[4] Liou EJW, Pai BCJ, Lin JCY. Do miniscrews remain stationary under orthodontic forces? American Journal of Orthodontics and Dentofacial Orthopedics. 2007;131(1):42–47.
[5] Nair A, Dhingra K, Kannan S. Evaluation of infrazygomatic crest bone thickness for orthodontic mini-implant placement using cone-beam computed tomography. Journal of Clinical and Diagnostic Research. 2019;13(6):ZC01–ZC05.
[6] Chen YJ, Chang HH, Lin HY, Lai EH, Hung HC, Yao CC. Stability of orthodontic mini-implants: A systematic review. Angle Orthodontist. 2007;77(2):29–34.
[7] Heo JM, Kim SJ, Park YC. Anatomical evaluation of the infrazygomatic crest area for skeletal anchorage using CBCT. Clinical Anatomy. 2021;34(5):762–770.
[8] Park JH, Kim SH, Kook YA. Clinical significance of maxillary sinus perforation by infrazygomatic crest screws. American Journal of Orthodontics and Dentofacial Orthopedics. 2022;161(6):783–790.
[9] Alharbi F, Almuzian M, Bearn DR. Miniscrew implant material properties and clinical performance: A systematic review. Clinical Oral Investigations. 2021;25(5):3215–3223.
[10] Motoyoshi M, Hirabayashi M, Uemura M, Shimizu N. Recommended placement torque when tightening orthodontic mini-implants. American Journal of Orthodontics and Dentofacial Orthopedics. 2006;130(4):442–445.
[11] Costa A, Raffainl M, Melsen B. Miniscrews as orthodontic anchorage: A preliminary report. Progress in Orthodontics. 2015;16:14.
[12] Lin J, Roberts WE. Skeletal anchorage in orthodontics: Biomechanical considerations of extra-alveolar mini-implants. International Journal of Orthodontics and Implantology. 2017;46:4–16.
[13] Melo AC, Andrighetto AR, Hirt SD. Stability of orthodontic mini-implants: A review of biomechanical and biological factors. Dental Press Journal of Orthodontics. 2017;22(4):87–97.
[14] Zhao Y, Zhang H, Liu Y. Finite element analysis of stress distribution around infrazygomatic crest mini-implants under orthodontic loading. Dental Materials Journal. 2022;41(1):145–152.
[15] Kim SH, Choi YS, Hwang EH. Finite element evaluation of insertion angles of infrazygomatic crest screws. Materials. 2024;17(5):1120.
[16] Wang Y, Liu D, Zhang J. Biomechanical evaluation of extra-alveolar skeletal anchorage using CBCT-based models. BMC Oral Health. 2024;24:924.
[17] Lee KJ, Park YC, Hwang CJ. Treatment of Class II malocclusion with en-masse distalization using skeletal anchorage. Angle Orthodontist. 2011;81(5):838–845.
[18] Patil PS, Dantkale AA, Kulkarni SS. Evaluation of maxillary distalization using infrazygomatic crest bone screws. Annals of Medical and Health Sciences Research. 2023;13(6):896–902.
[19] Gill G, Jain RK, Kalra A. Vertical control using infrazygomatic crest anchorage: A clinical study. Journal of Oral Biology and Craniofacial Research. 2023;13(3):283–289.
[20] Nandan H, Singh G, Kaur H. Success and failure rates of infrazygomatic crest bone screws: A systematic review. Journal of Contemporary Orthodontics. 2024;8(2):114–124.
[21] Chang C, Liu SSY, Roberts WE. Orthodontic treatment with extra-alveolar skeletal anchorage.Seminars in Orthodontics. 2015;21(1):58–70.
[22] Nguyen T, Huynh T, Pham D. Accuracy of CBCT-guided placement of orthodontic mini-implants. Australian Orthodontic Journal. 2023;39(1):64–70.
[23] Madhu ST, Raj A, Kumar P. Digital planning and guided placement of infrazygomatic crest mini-implants. Journal of Contemporary Orthodontics. 2025;9(1):133–135.
[24] Papageorgiou SN, Zogakis IP, Papadopoulos MA. Failure rates and associated risk factors of orthodontic miniscrew implants. American Journal of Orthodontics and Dentofacial Orthopedics. 2012;142(5):577–595.
[25] Smith RJ, Burstone CJ. Biomechanics of skeletal anchorage in orthodontics. Angle Orthodontist. 2021;91(4):534–540.
[26] Oliveira DD, Diniz-Freitas M, Gómez M. Risk factors associated with orthodontic mini-implant failure. Journal of Orthodontic Research. 2024;12(1):21–29.
[27] Kim SJ, Choi TH, Lee KJ. Clinical predictors of infrazygomatic crest screw success. Korean Journal of Orthodontics. 2020;50(5):311–318.
[28] Lee JH, Baek SH, Kim TW. Soft tissue complications associated with orthodontic mini-implants. Journal of Orthodontics. 2018;45(3):212–221.
[29] Chen PH, Wang YC, Lin SY. Clinical outcomes of infrazygomatic crest screws with sinus penetration. Journal of Clinical Orthodontics. 2020;54(8):456–464.
[30] Buzatu M, Rusu LC, Grigorescu C. Comparative evaluation of buccal shelf and infrazygomatic crest anchorage systems. European Journal of Orthodontics. 2019;41(3):251–259.