Nanomaterials are redefining technological boundaries across energy, environment and healthcare due to their unique size-dependent physical, chemical and optical properties. Next-generation nanomaterials including 2D materials, quantum dots, metal-organic frameworks, perovskites and bio-nanocomposites offer unprecedented efficiency and multifunctionality. In energy, nanostructured electrodes and perovskite solar cells have pushed efficiencies beyond 26%. In environment, MOFs and nano-adsorbents enable selective removal of CO2, heavy metals and microplastics. In healthcare, theranostic nanoparticles and nano-biosensors provide targeted drug delivery and early disease diagnosis. This review synthesizes recent advances from 2020-2025, compares performance metrics, and outlines challenges in scalability, toxicity and regulation. We also present a roadmap for 2026-2035 for commercial translation. Integrating AI-driven materials discovery with green synthesis will accelerate next-generation nanomaterials from lab to market. These materials are key to achieving net-zero energy goals and SDG-3 and SDG-6 targets.
Introduction
The 21st century faces major challenges related to sustainable energy, environmental pollution, and healthcare accessibility. Conventional materials are approaching their performance limits, creating demand for advanced nanomaterials with unique properties such as quantum effects, high surface area, and tunable electronic structures. Next-generation nanomaterials—including 2D materials, quantum dots, metal-organic frameworks (MOFs), perovskite nanocrystals, and bio-nanocomposites—offer promising solutions across energy, environmental, and medical fields. However, issues such as toxicity, high production costs, scalability, and regulation remain barriers to widespread adoption.
1. Energy Applications
Nanomaterials are transforming energy storage and conversion technologies.
Advanced batteries and supercapacitors:
Nanostructured materials improve battery capacity, charging speed, and durability. Silicon nanowires provide much higher theoretical capacity than graphite, while MXenes and graphene-based materials enhance conductivity and cycle stability.
Solar energy and hydrogen production:
Perovskite nanocrystals improve solar cell efficiency, while plasmonic nanoparticles enhance light absorption. Nanocatalysts such as platinum single atoms on graphene and MoS? nanosheets improve hydrogen production through efficient water splitting.
2. Environmental Applications
Nanomaterials provide efficient methods for pollution control and resource recovery.
Water purification:
MOFs, graphene oxide membranes, titanium dioxide nanotubes, and magnetic nanoparticles remove heavy metals, dyes, pharmaceuticals, and microplastics through adsorption, filtration, and photocatalysis.
Air pollution control and carbon capture:
Nanomaterials such as ZIF-8 MOFs capture carbon dioxide, carbon nanotube filters remove fine particulate matter, and photocatalytic nanomaterials help convert CO? into useful products.
3. Healthcare Applications
Nanotechnology is enabling advanced diagnosis, treatment, and regeneration.
Nanomedicine and drug delivery:
Gold nanorods enable targeted cancer therapy, lipid nanoparticles support mRNA vaccine delivery, quantum dots improve medical imaging, and DNA nanorobots offer targeted therapeutic approaches.
Biosensors and diagnostics:
Graphene-based sensors, MXene wearable devices, and nanozymes provide rapid and sensitive detection of diseases and biological markers.
Regenerative medicine:
Hydroxyapatite nanoparticles and nanofiber-based materials support bone repair and wound healing by improving cell growth and tissue regeneration.
4. Challenges
Despite significant progress, several limitations must be addressed:
Toxicity: Nanoparticles may generate reactive oxygen species and accumulate in biological systems.
Large-scale production: Manufacturing advanced nanomaterials remains expensive and difficult to standardize.
Regulatory issues: Lack of global safety guidelines creates uncertainty for commercialization.
Sustainability concerns: Energy-intensive production methods and environmental impacts require attention.
5. Future Roadmap (2026–2035)
Future developments are expected to accelerate through artificial intelligence, advanced manufacturing, and safer designs:
2026–2028: AI-assisted discovery of new nanomaterials, commercialization of silicon nanowire batteries.
2029–2032: Higher-efficiency perovskite solar cells, large-scale MOF-based water purification systems.
2033–2035: Clinical development of nanorobots, pollution-monitoring nanosensor networks, and self-healing nanomaterials for construction.
Conclusion
Next-generation nanomaterials are no longer lab curiosities. With efficiencies >25% in solar, 99.9% pollutant removal, and fg-level biosensing, they address energy, environment and healthcare simultaneously. Success depends on green synthesis, AI-driven design, and strict safety frameworks. By 2035, these materials will be central to net-zero and precision medicine goals. Interdisciplinary collaboration is essential to translate nano-innovation into global impact.
1) Conflict of Interest: The author’s declare no conflict of interest.
2) Funding: No funding was received.
3) Acknowledgement: Author’s thanks Brahmanand College, Kanpur for support.
References
[1] Kroto, H. W. et al. C60: Buckminsterfullerene. Nature 318, 162-163 (1985).
[2] Iijima, S. Helical microtubules of graphitic carbon. Nature 354, 56-58 (1991).
[3] Novoselov, K. S. et al. Electric field effect in atomically thin carbon films. Science 306, 666-669 (2004).
[4] Chan, W. C. W. & Nie, S. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281, 2016-2018 (1998).
[5] Furukawa, H. et al. The chemistry and applications of metal-organic frameworks. Science 341, 1230444 (2013).
[6] Kojima, A. et al. Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. JACS 131, 6050-6051 (2009).
[7] Chen, Q. Z. et al. Bioactive nanocomposites for tissue engineering. Prog. Mater Sci. 54, 1-54 (2009).
[8] Grand View Research. Nanomaterials Market Size Report 2024-2030 (2024).
[9] Chan, C. K. et al. High-performance lithium battery anodes using silicon nanowires. Nat. Nanotechnol. 3, 31-35 (2008).
[10] Anasori, B. et al. Two-dimensional metal carbides and nitrides. Nat. Rev. Mater. 2, 16098 (2016).
[11] Ji, X. et al. Graphene-sulfur composite as cathode for Li-S batteries. Nano Lett. 9, 3843-3848 (2009).
[12] Atwater, H. A. & Polman, A. Plasmonics for improved photovoltaic devices. Nat. Mater. 9, 205-213 (2010).
[13] Deng, J. et al. Highly active and stable black phosphorus single-atom catalyst for HER. Nat. Commun. 11, 699 (2020).
[14] Nair, R. R. et al. Unimpeded permeation of water through graphene oxide membranes. Science 335, 442-444 (2012).
[15] Fujishima, A. & Honda, K. Electrochemical photolysis of water at a semiconductor electrode. Nature 238, 37-38 (1972).
[16] Zhang, W. et al. Magnetic nanoparticles for microplastic removal. Environ. Sci. Technol.54, 11832-11840 (2020).
[17] De Volder, M. F. L. et al. Carbon nanotubes: present and future commercial applications. Science 339, 535-539 (2013).
[18] Ong, W. J. et al. Graphitic carbon nitride for CO2 reduction. Chem. Rev. 118, 10451-10484 (2018).
[19] Huang, X. et al. Cancer cell imaging and photothermal therapy using Au nanorods. JACS 128, 2115-2120 (2006).
[20] Hou, X. et al. Lipid nanoparticles for mRNA delivery. Nat. Rev. Mater. 6, 1078-1094 (2021).
[21] Li, S. et al. A DNA nanorobot for tumor-targeted drug delivery. Nat. Biotechnol.36, 258-264 (2018).
[22] Seo, G. et al. Rapid detection of COVID-19 using graphene FET. ACS Nano14, 5135-5142 (2020).
[23] Gao, L. et al. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nat. Nanotechnol.2, 577-583 (2007).
[24] Li, W. J. et al. Electrospun nanofibrous scaffolds for tissue engineering. Biomaterials 23, 2467-2478 (2002).
[25] Nel, A. et al. Toxic potential of materials at the nanolevel. Science 311, 622-627 (2006).
[26] Klaessig, F. et al. Nanotechnology regulation and policy worldwide. Wiley Interdiscip. Rev. Nanomed. 13, e 1626 (2021).