Ijraset Journal For Research in Applied Science and Engineering Technology

Abstract

Kiratatikta (Swertia chirayita (Roxb.) H. Karst.) is a herb with diverse medicinal properties. Name of the plant itself signifies that it is more of bitter taste and this bitterness is due to presence of different active principles like Amarogentin, Swertiamarin and Mangiferin etc. By these active principles it has shown pharmacological activities like Anticancer, and CNS depressant Antiviral activity. Kiratatikta is popularly known for its traditional uses in Jwara, Raktapitta, pidaka and many more. As this herb is now endangered species, another herb called Kalamegha (Androghaphis paniculata) which is having similar properties like Kiratatiktha is being used as substitute. Some authors mention it as adulterant.

Introduction

I. INTRODUCTION

Kiratatiktha botanically identified as Swertia chirayita (Roxb.) H. Karst belongs to Gentianaceae family. In India, 40 species of Swertia are recorded [1]. S. chirayita was first described in 1814 by Roxburgh under the name of Gentiana chyrayta2. This ethnomedicinal herb is known mostly for its bitter taste caused by the presence of different chemical constituents such as amarogentin- most bitter compound isolated till date, swerchirin, swertiamarin, and other bioactive compounds that are directly associated with human health welfare[3]. Its widespread uses in traditional medicine have resulted in over-exploitation from the natural habitat and it is now on the verge of extinction in the wild. So now it is a critically endangered medicinal herb that grows at high altitudes in the sub-temperate regions of the Himalayas between 1200 and 2100 m altitudes from Kashmir to Bhutan [4]

 The references about the plant Kiratatikta is found in brihatrayi especially in Ganas and some of therapeutic usage have been mentioned. We can see eloborated more description in  many Nighantus. The herb Kiratatikta is popularly familiar with names like Bhunimba. The present article intend to review in detail about Kiratatikta mentioned in ayurvedic classics along with detailed information available in different sources.

II. GENERAL INFORMATION REGARDING KIRATATIKTHA MENTIONED GANAS OF DIFFERENT CLASSICS

Our preceptors classified the drugs based on pharmacodynamics and therapeutic value generally and also by their morphological features and properties. Kiratatikta (Swertia chirayita (Roxb.) H. Karst) classified under various such groups is enlisted below.

Table: 1 showing classification according to different Classics [5,6,7,8,9,10,11,12,13,14,15]

III. NIRUKTI [16, 17, 18]

The nirukti of the drug –Kiratatikta (Swertia chirayita (Roxb.) H. Karst) mentions its taste is purely bitter and its habitat i.e, its available in ‘Kirata desha’- which is North east part of India.

1. ‘??????????’- ?????: ????????????? ?????: | ??????????:?(?.?.????)

?????? ??? ???? | ?????????: | ???????:, ???????????: ||

2. ??????????? ???????????????????: - ?????????????? ????????????? |     ??????????? ???????? || (?.??.)

3. ?????????? – ???????? ????????????????? ???????? ??? | (?????????-???????)

IV. SYNONYMS

Table: 2: Showing synonyms according to different authors. [8,9,10,11,12,13,14,15]

V. VERNACULAR NAMES

Table: 3. Showing vernacular names: [19, 20, 21]

VI. Taxonomical Position[22, 23]

Table no.4 Taxonomic position of Kiratatikta

VII. HABITAT and HABIT[19]

1. Global: It is specially grown in Nepal and Bhutan.
2. India: Distributed in temperate Himalayas between 1200 – 3000 m altitude and in Khasi hills in Meghalaya, Arunachal Pradesh and northeast (1200-1500m) covering Himachal Pradesh,Uttaranchal, Uttarpradesh, Sikkim.
3. Habit
4. It is erect, branched, robust, annual herb.
5. Stem: 1m long and 6mm in diameter, glabrous, yellowish-brown to purplish, slightly quadrangular above and cylindrical below, large and continuous.
6. Leaves: opposite, cauline, broad at base, ovate or lanceolate, entire, acuminate, glabrous, usually with 5-7 prominent lateral veins, branching from axils of the leaves which ramify further into paniculate inflorescence.
7. Flowers: small, numerous, greenish yellow, tinged with purple, in profuse panicles, ovoid.
8. Fruit: a capsule with numerous, minute reticulated seed, 0.25- 0.55 mm long and 0.16- 0.45 mm broad irregularly ovoid. Seeds: many smooth, 0.5 mm, polyhedral. Flowering: July – October Fruiting: October – December

VIII. CHEMICAL CONSTITUENTS [19, 20]

Mangiferin, Swertiamarin, Swertianin, Chiratanin, Enicoflavine, Gentianine, Gentiocrucine, Chiratin, Amarogentin, Gentiopicrin, Cerolic, Oleic, Leucine, Arginine, Stearic acid,Glutamic acid, Chiratenol, Methionine, Kairatenol, Swertanone, Swertenol, Episwertenol, Ursolic acid, Teraxerol , B sitosterol

IX. Rasa Panchaka[8,9,10,11,12,13,14,15]

The science of Ayurveda explains Pharmacodynamics of a drug in unique way i.e, in terms of Rasapanchaka i.e, Rasa, Guna, Veerya, Vipaka, Doshakarma. This description we find mainly in lexicons.

Table: 5- Showing Rasa panchaka of Kiratatikta according to different authors

X. THERAPEUTIC USES [24]

1. Jwara: Hot infusion of Kiratatikta mixed with Dhanyaka leaves alleviates fever immediately. (Siddha.Bhaishajya manimala.4/32)
2. Grahani: Kiratadhya churna (Charaka chikitsa.15/137-140) Bhunimbadhya churna (Charaka chikitsa.15/132-133).
3. Oedema: Paste of Kiratatikta and Shunthi destroys oedema which is chronic and caused by three doshas. ( Charak chikitsa.12/42)
4. For purifying breast milk: Decoction of Katuka, Guduchi, Saptaparna bark, Sunthi and Kiratatikta is administered. (Charaka chikitsa30/261-262)
5. Eruptive boils: Bhunimbadi kashaya.( Gada Nigraha.2/ 40-66)
6. Raktapitta (Intrinsic haemorrhage): Kiratatikta mixed with sandal is beneficial in the disease. (Charaka chikitsa.4/74-76)

XI. RESEARCH PROFILE

Amarogenin constituent has shown as Anticancer activity[25] and Antidiabetic activity [26]

Swertiamarin has proven for CNS depressant[27] and Anti diabetic activity[28]

Mangiferin has shown Antiviral activity[29].

S. chirayita extracts showed anti-hepatitis B virus (anti-HBV) activities[30]

XII. PARTS USED20 And POSOLOGY20

Whole plant i.e. Panchanga            

Posology:- Powder form: 1 – 3 gm     Decoction: 20-30 ml.                                     

XIII. CLASSICAL FORMULATIONS31, 32, 33

Table: 6. Showing vishista yogas of Kiratatikta

XIV. SUBSTITUTES[34] And ADULTERANTS[34]

A. Substitutes

1. Swertia purpurascens Wall.
2. S.decussata Nimmo ex Grah.
3. S.chinensis Franchet.
4. S.paniculata Wall.
5. S.perennis Linn.
6. S.lawii Burkill                             
7. S.affinis C. B. Clarke.
8. Exacum bicolor Roxb.  
9. E.tetragonum Roxb.
10. Erythraea roxburghii G.Don.
11. Enicostemma littorale Blume.

B. Adultrants[34]

1. Swertia angustifolia Buch.Ham.ex D.Don
2. Swertia alata Royle ex.C.B.Clarke
3. Rubia cordifolia Linn
4. Andrographis panniculata Nees.

Conclusion

Kiratatikta – a herb with bitter taste, it has got lot of medicinal values. Swertia chirayata is now considered as endangered species because of its extensive use. There are many species are taken substite for Kiratatikta, but popularly Kalamegha- (Andrographis paniculata) which is having similar properties is being used instead of Kiratikta. In ayurvedic classics the herb has been one of the key ingredient in many preparations used in Jwara, Raktapitta, Shotha etc even used in liver disorders.

References

[1] Clarke C. B. (1885). Verbenaceae, in The Flora of British India, Vol. IV, ed Hooker J. D. (London: L. Reeve and Co; ), 560–604. [2] Scartezzini P., Speroni E. (2000). Review on some plants of Indian traditional medicine with antioxidant activity. J. Ethnopharmacol. 71, 23–42. 10.1016/S0378-8741(00)00213-0 [3] Joshi P., Dhawan V. (2005). Swertia chirayita—an overview. Curr. Sci. 89, 635–640. [4] Bentley R., Trimen H. (eds.). (1880). Medicinal Plants. London: J and A Churchill. [5] Agnivesa- Carakasamhita Vol-1 Edited with “Vaidyamanorama” Hindi Commentary along with special deliberation by Acharya Vidyadhar Shukla & Prof. Ravi Dutt Tripathi , Chaukhambha Sanskrit Prakashan, Delhi. 2nd edition 2009. a) Sutrasthana ch 4, Sl No.18,29. Page No-74,75. b) Vimanasthana ch 8, Sl No.143,Page No.664 [6] Maharshi Sushruta- Sushruta Samhita Edited with ‘Sushruta Vimarshini’ Hindi Commentary by Dr.Anant Ram Sharma, Chaukhambha Surbharati Prakashan,Varanasi. 2nd edition 2012. Sutrasthana Ch 38. Sl No.6-7. Page No,294. [7] Vrddha Vagbhata- Astanga samgraha With the Sasilekha Sanskrit Commentary By Indu. Prologue in Sanskrit & English by Prof.Jyotir Mitra. Chowkhamba Sanskrit Series Office Varanasi. 3rd Edition 2012. a) Sutrasthana ch 15.Sl No.6,Page No.131. b) Ch 16,Sl No.9,Page No.133. c) Ch No.18,Sl No.14,Page No.145 [8] Shri Bhavamisra- Bhavaprakasa Nighantu (Indian Materia Medica) by Prof.K.C.Chunekar, Chaukhambha bharati academy Varanasi. Revised & Enlarged Edition 2010. Sl No.153-155. Page No.70. [9] Kaiyadeva- Kaiyadeva Nighantu Edited and Translated by Dr.P.V.Sharma and Dr.Sharma guru Prasad, 1st edition 1979. Chaukhambha Surbharati Prakashana Varanasi. Aushadha varga, Sl No.889-891. Page No.165 [10] Madanapala- Madanpala Nighantu by Dr.J.L.N.Sastry, Chaukhambha Orientalia Varanasi, 1st Edition 2010, Abhayadi Varga, Sl No.143-144. Page No.104-107. [11] Dr.Priyavrat Sharma- Priya Nighantu Along with the author’s Hindi Commentary entitled “PADMA”, Chaukhambha Surbharati Prakashana. 2ndedition. Shatpushpadi Varga, Sl No.133-134. Page No.100 [12] Pandit Narahari- Raj Nighantu Edited with “Dravyagunaprakasika” Hindi Commentary by Dr.Indradeo Tripathi, Krishnadas Academy. 2nd Edition 1998. Prabhadradi Varga. Sl No.15-16. Page No.266. [13] .Acarya Sodhala- Sodhala Nighantuh, Text with English-Hindi Commentaries by Prof.(Dr.)Gyanendra Pandey., Chowkhamba Krishnadas Academy Varanasi, 1st edition 2009, Guducyadi Vargah, Sl No.121-122.Page No.2 [14] Bapalala G.Vaidhya. Nighantu Aadarsh Uttarardh, Chaukhambha Bharati Academy Varanasi. 2nd Edition 1999. Kiratadi Varga, Page No.70-72 [15] Dhanvantari Nighantu- Edited by Aacharya Priyavrat Sharma & Translated by Dr.Guru Prasad Sharma, Chaukhambha Orientaliya Varanasi. 2nd edition 1998. Guduchyadi Varga. Sl No.33-35. Page No 22 [16] Raja Radhakanta Dev- Shabdakalpadruma 2nd Kanda, Naga Publishers Delhi, 2nd edition 2003. Page-128 [17] Haragovinda Shastri- Namalinganusasana or Amarakosa of Amarasimha with the ramasrami commentary of Bhanuji Dixita, Kanda-2, Varga-4, Vanoushdhi Varga, Chaukhambha Sanskrit Sansthan, Varanasi. 4th edition 2001. Page-226 [18] Tarkavachaspati Sri Taranath Bhattacharya – Sabdastoma mahanidhi ( A Sanskrit dictionary), Chowkhamba Sanskrit Series Varanasi. 3rd edition 1967. Page- 24, 101, 115, 122, 135, 311, 326. [19] K.V.Billore, M.B.Yelne, T.J.Dennis, B.G.Chaudhary- Database On Medicinal Plants Used In Ayurveda. CCRAS, Dept. of AYUSH, Govt.of India New Delhi. Volume 7. 2005. Page- 226 – 243. [20] Lt.Colonel K.R.Kirtikar & Major B.D.Basu- Indian Medicinal Plants, 3rd Volume, International Book Distributors Deharadun. 2nd edition. Page- 166 [21] The Ayurvedic Pharmacopoeia of India, Part 1, Volume-1, Govt. of India, Ministry of health and family Welfare, Dept. of AYUSH. [22] https://www.gbif.org/species/5596317 [The Global Biodiversity Information Facility [23] https://en.wikipedia.org/wiki/Swertia [24] P.V.Sharma- Classical uses of Medicinal Plants, Chaukhambha Vishvabharati. Reprint 2004. Page- 504, 100 [25] Saha P., Mandal S., Das A., Das S. (2006). Amarogentin can reduce hyperproliferation by downregulation of Cox-II and upregulation of apoptosis in mouse skin carcinogenesis model. Cancer Lett. 244, 252–259. 10.1016/j.canlet.2005.12.036 [26] Phoboo S., Pinto M. D. S., Barbosa A. C. L., Sarkar D., Bhowmik P. C., Jha P. K., et al.. (2013). Phenolic-linked biochemical rationale for the anti-diabetic properties of Swertia chirayita (Roxb. ex Flem.) Karst. Phytother. Res. 27, 227–235. 10.1002/ptr.471 [27] Bhattacharya S. K., Reddy P. K., Ghosal S., Singh A. K., Sharma P. V. (1976). Chemical constituents of Gentianaceae. XIX. CNS-depressant effects of swertiamarin. Indian J. Pharm. Sci. 65, 1547–1549. 10.1002/jps.260065103 [28] Vaidya H., Goyal R. K., Cheema S. K. (2013). Anti-diabetic activity of swertiamarin is due to an active metabolite, gentianine, that upregulates PPAR-? gene expression in 3T3-L1 cells. Phytother. Res. 27, 624–627. 10.1002/ptr.4763 [29] Zheng M. S., Lu Z. Y. (1990). Antiviral effect of mangiferin and iso-mangiferin on herpes simplex virus. Chinese Med. J. 103, 160–165. [30] Zhou N. J., Geng C. A., Huang X. Y., Ma Y. B., Zhang X. M., Wang J. L., et al.. (2015). Anti-hepatitis B virus active constituents from Swertia chirayita. Fitoterapia 100, 27–34. 10.1016/j.fitote.2014.11.01 [31] Shri Ambikadattshashtri – Bhaisajyaratnavali. Chaukhambha Sanskrit Samsthan Varanasi. 15th edition 2002. Page. 61, 633, 124, 125, 72 [32] Vaidya Pandit Haripannaji - Rasayoga Sagar Vol 2. Chowkhamba Krinadas Academy Varanasi. Reprint 2010. Page. 57, 204-205, 224-225, 492, 179, 30 [33] Shri Chandra Raja Bhandari – Vanaspati Chandrodaya. Chaukhambha Sanskrit Samsthan Varanasi. 2nd edition 2010. Page. 26-27 [34] Shri Bhavamisra- Bhavaprakasa Nighantu (Indian Materia Medica) by Prof.K.C.Chunekar, Chaukhambha bharati academy Varanasi. Revised & Enlarged

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Copyright © 2023 Dr. Shivananda B. Karigar , Dr. Praveen Kumar K M. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.