A Study to Assess the Effectiveness of Structured Teaching Program on Knowledge Regarding Umbilical Cord Stem Cell Therapy among Health Care Professional Students

Abstract

Umbilical cord stem cell therapy involves using stem cells from umbilical cord blood or tissue to treat various medical conditions. These stem cells have the potential to differentiate into different types of cells, which can aid in repairing damaged tissues and organs, as well as modulating the immune system. It\'s been explored for a range of conditions including blood disorders, autoimmune diseases, and neurological disorders. However, while it shows promise, its effectiveness and safety are still being researched and evaluated through clinical trials. Umbilical cord stem cell therapy utilizes stem cells derived from umbilical cord blood or tissue for medical treatment. These stem cells possess the unique ability to differentiate into various cell types, offering potential therapeutic benefits for a wide range of medical conditions. Research and clinical trials have shown promising results in treating blood disorders, autoimmune diseases, neurological disorders, and more. However, further studies are required to fully understand its efficacy, safety, and long- term effects. Quantitative research approach was adopted for the study. Health care professional students are taken for the study by Purposive sampling technique. Pretest and Post-test knowledge of health care professional students were assessed by structured knowledge questionnaire. Analysis done by descriptive and inferential statistics. The result shows that mean posttest knowledge score (10.6) was highly significant than pretest knowledge score (7.2). The calculated t value (t=8.98) was higher than the table value (t=2.00) at 0.05 level of significance. It confirms that the education was effective in increasing the knowledge of health care professional students. Conclusion; the structured teaching programme was effective in improving the knowledge of healthcare professional students of St. James college of pharmaceutical science, Chalakudy.

Introduction

Stem cells, particularly those from umbilical cord blood, have a notable history starting from the early 1970s, with the first successful cord blood transplant performed in 1988. Cord blood has become an important alternative to bone marrow for transplantation due to easier availability, less strict matching requirements, and lower risk of complications. By 2012, over 12,000 cord blood transplants had been conducted worldwide, treating around 80 life-threatening diseases.

Stem cells are characterized by their ability to self-renew, differentiate into specialized cells, and replenish tissues. While embryonic stem cells are pluripotent, most well-studied stem cells, including those from umbilical cords, are multipotent and can form multiple cell types.

Umbilical cord stem cells are advantageous because they are readily available, less ethically controversial than embryonic stem cells, and useful in treating a variety of diseases, including blood disorders and metabolic conditions. Cord blood banking is growing, with hundreds of thousands of units stored globally.

The study aims to evaluate the effectiveness of a structured teaching program to improve healthcare professional students’ knowledge about umbilical cord stem cell therapy. It highlights the need for education on this topic due to students’ limited awareness, and the potential of stem cell therapy in treating diseases like leukemia and diabetes. The research follows a conceptual framework based on general system theory to guide the assessment and teaching intervention.

Conclusion

The present study aimed to assess the knowledge of health care professional students regarding umbilical cord stem cell therapy. Data was collected from health care professional students. Collected data was analysed by using descriptive and inferential statistics and presented in the form of tables and graphs. The effective structured teaching programme was determined by paired t test. Chi-square was computed to find out the association between level of knowledge of health care professional students and their selected demographic variables. The findings of the study revealed that there is a significant improvement in the knowledge score of health care professional students after the structured teaching programme. The levels of knowledge of health care professional students had no significant association with their selected demographic variables.

References

[1] https://www.stemcyte.com/stemcyteadvantage [2] https://www.bartleby.com/essay/Stem -cell Research-Thesis- EAACA30651C6D909 [3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495455) [4] https://www.rsct.ir/en/News/articleType/ArticleView/articleld/1278/Top-5- Influencers-in-the-Global-Cord-Blood-Banking-Market [5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442723/ [6] Nicolas H. Zech, Karl-Heinz Preisegger, and Peter Hollands. Stem cell therapeutics reality versus hype and hope :published online 2010 Dec 8. [7] https://www.viacord.com/treatments-and-research/how-cord-blood-is-ed today/ [8] Mark L. Weiss Deryl L Troyer Stem cells in the umbilical cord Stem Cell:2006. [9] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753204/ [10] https://www.babycell.in/pdf/UCB-Statistics.pdf [11] https://www.unmc.edu/stemcells/educational-resources/importance.html [12] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209739/ [13] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567024/ [14] https://www.cb-association.org/myths-and-facts [15] https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884- 016- 0863-6 [16] https://www.hilarispublisher.com/proceedings/effect-of-educational- intervention- on-knowledge-and-attitude-of-nursing-students-regarding-stem- cells-therapy- 18556.html [17] https://ijneronline.com/AbstractView.aspx?PID=2021-9-2-8 [18] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683846/ [19] https://www.ijene.org/article.asp?issn=2230-7354;year-2017;volume=18;issue=1;spage=48:epage=53; aulast- Premkumahttps://nursekey.com/kings-conceptual-system-and-theory-of-goal- attainmnursing-practice/ [20] https://libguides.usc.edu/writingguide/literaturereview [21] IOSR Journal of Nursing and Health Science (IOSR-JNHS) - ISSN: 2320- 1959.p- ISSN: 2320-1940 Volume 4, Issue 2 Ver. V (Mar-Apr. 2015), PP 44-53 www.iosrjournals.org [22] https://iiste.org/Journals/index.php/JHMN/article/view/440 [23] JournalofNurseMidwiferyandMaternalHealthVolume5Number3: September- December2019DOI:http://dx.doi.org/10.21088/jnmmh.2454.7506.5319.5 [24] esearchgate.net/publication/301536762_Health_care_professionals knowledg e_attitudes_and_practices_relating_to_umbilical_cord_blood_banking_and d onation_An_integrative_review [25] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209739/ [26] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683846/ [27] https://www.researchgate.net/publication/344783437_Effectiveness_of_Struct ured_Teaching_Programme_on_Knowledge_Regarding_Cord_Blood_Bankin g_among_Staff_Nurses [28] https://ijneronline.com/HTMLPaper.aspx?Journal-International%20Journal% 20of%20Nursing%20Education%20and%20Research; PID-2021-9-2-8 [29] https://ajner.com/AbstractView.aspx?PID=2017-7-4-11 [30] https://ijmrr.medresearch.in/index.php/ijmrr/article/view/1270/2376 [31] https://publichealth.medresearch.in/index.php/ijphr/article/view/46/363 [32] http://www.internationaljournalofcaringsciences.org/docs/37_ozturk_ABSTR ACT_10_1.pdf [33] http://www.journalcra.com/sites/default/files/issue-pdf/8646.pdf [34] https://pubmed.ncbi.nlm.nih.gov/26650509/ [35] https://pubmed.ncbi.nlm.nih.gov/32162161/ [36] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432540/ [37] https://www.researchgate.net/publication/346053142_Therapeutic_efficacy_of_umbilical_cord-_derived_stem_cells_for_diabetes_mellitus a meti analysis_study [38] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052613/ [39] https://pubmed.ncbi.nlm.nih.gov/28873511 [40] https://www.walshmedicalmedia.com/open-access/evaluation-of-immune- response-to-intravenously-administered-human-cord-blood-stem-cells-in-the- treatment-of-symptoms-rel-40091.html [41] https://www.researchgate.net/publication/328022058 Therapeutic_potency_of_cord_blood_stem_cells_in_patients_with_cerebral_palsy_A_systemic_literat ure_review [42] Solves P, López M, Mirabet V, Blanquer A, Roig R, Perales A. Characteristics of umbilical cord blood units collected from preterm deliveries. GynecolObstet Invest: 2009;68(3):181-5. doi: 10.1159/000232382. E pub 2009 Aug 6. PMID: 19672086. [43] https://www.nature.com/articles/s41392-022-01059-y [44] https://www.researchgate.net/publication/360553187_Ultasoundguided_intraa rticular_injection_of_expanded_umbilical_cord_mesenchymal_stem_cells_in_ knee_osteoarthritis_a_safetyefficacy_study_with_MRI_data [45] https://www.bluehorizoninternational.com/wp- content/uploads/2019/11/BHI_Umbilical-Cord-Blood.pdf [46] Wang L, Huang S, Li S, Li M, Shi J, Bai W, Wang Q. Zheng L, Liu Y. Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cell Therapy for Rheumatoid Arthritis Patients: A Prospective Phase I/II Study. Drug Des DevelTher. https://doi.org/10.2147/DDDT.S2256132019:13:4331-4340 [47] Zhang C, Yin X, Zhang J, Ao Q, Gu Y, Liu Y. Clinical observation of umbilical cord mesenchymal stem cell treatment of severe idiopathie pulmonary fibrosis: A case report. ExpTher Med. 2017 May; 13(5):1922-1926. doi: 10.3892/etm.2017.4222. Epub 2017 Mar 10. PMID: 28565787; PMCID: PMC5443299. [48] Lavik E, Teng YD, Snyder E, Langer R. Seeding neural stem cells on scaffolds of PGA, PLA, and their copolymers. Methods Mol Biol. 2002;198:89-97. doi: 10.1385/1-59259-186-8:89. PMID: 11951644. [49] Angelini P, Markwald RR. Stem cell treatment of the heart: a review of its current status on the brink of clinical experimentation. Tex Heart Inst J. 2005:32(4):479-88. PMID: 16429891; PMCID: PMC1351818. [50] https://www.researchgate.net/publication/333015026 [51] https://www.concedirect.com/topics/medicine-und-dentistry/evaluation [52] https://www.questionpro.com/blog/research-design/ [53] https://sites.google.com/site/aryamsn/syllabus/syllabus-research/research- approach-design#:-:text [54] https://study.com/learn/lesson/research-variables-types-independent- dependent.html [55] hitps://www.statisticshowto.com/dependent-variable-definition/ [56] https://www.scribbr.com/methodology/Independent-and-dependent-variables/ [57] https://www.statology.org/extraneous-variable/ [58] https://homework.study.com/explanation/what-is-the-research-setting-in- methodology.html [59] https://www.coursehero.com/file/p7m77ej5/POPULATION-The-entire-set-of- individuals-or-objects-having-some-common/ [60] https://www.questionpro.com/blog/sample/ [61] https://www.questionpro.com/blog/types-of-sampling-for-social-research/ [62] https://www.tdlpathology.com/tests/specimens/specimen-rejection-criteria/ [63] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044655/ [64] https://www.sciencedirect.com/topics/engineering/development-tool [65] https://www.frase.io/tools/meta-description-generator/ [66] https://www.searchenginejournal.com/content-marketing/top-tools-create- better- content/ [67] https://www.indeed.com/career-advice/career-development/reliability-in- research [68] https://www.sciencedirect.com/topics/computer-science/data-collection- procedure [69] https://www.surveymonkey.com/mp/developing-data-analysis-plan/ [70] https://scholar.google.co.in/ [71] Suresh.K. Sharma nursing research and statistics: 3rd edition: Elsevier:2017 [72] Armson B. (2005). Umbilical cord blood banking: implications for Perinatal care Providers, JOGC March 156:263-74 [73] Hend M. Azzazy, and latera P. Mohamed Effect of Edventional Interventions on Knowledge and Attitude of Nursing Students Regarding Stem Cell Therapy.( Internet) Issue ( cited 2016 mar- april). Available from 1058 Journal of Nursing and Health Science (IOSR-JNHS)e-ISSN: 2320-1959. ISSN: 2320-1940 Volume 5, Issue 2 Ver. IV (Mar-Apr. 2016), PP75- 80www.iosrjournals.org [74] Ishita shah (Internet). Issue (cited April 2020). Available from Indian Journal of Public Health Research and Development 11(3): 126 [75] JayashreeAjith, Lini E Thomas.Effectiveness of struchered teaching programme on knowledge regarding stem cell therapy and its importance amoung nursing student.( Internet) Issue. ( Cited 2019 sep- nov). Available from:DOI:http://dx.doi.org/10.21088/jnmmh.2454.7506.5319.5 [76] Bhattacharya N, Mitra R, Mukharjee K L, et., al. (2002). Can human cortical tissue Transplant (up to 20 weeks) sustain its metabolic and oxygen requirement in With parkinsonism. oClini.exp.obstetgynaecol: 29(4). [77] SusanMattson,Judy E.newbornnursing: Saunders.4 edition;2010 [78] A. Parthasarathy, IAP textbook of pediatrics: Jaypee Brothers Medical Pub. 6 th edition; 2016 [79] Annamma Jacob stem cell therapy and it\'simportance, A comprehensive textbook of midwifery and gynaecological nursing 3rd edition:2015 85. Storer.et al mesenchymal stem cell therapy on the time course of pulmonary remodelling depend on the etiolology of lung injury.Transplant procedure 20 th edition: 2005

Copyright

Copyright © 2025 Dency C D, Amarjith K. H, Athira U, Liya V. R, Mariya Paul. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.