Aspirin is 2-acetoxy benzoic acid. It is one of the derivatives of Benzoic acid. It is white crystalline fine powder. Aspirin is acetylated product. This drug is under non-steroidal anti-inflammatory drug in which they block cyclooxygenase receptor by inhibiting COX pathway.
The drug can block the production of prostaglandin derivative. Therefore they can be used as an analgesic cum anti-inflammatory.
As we know prostaglandin is the inflammation mediator in human body, therefore, by blocking their production, Aspirin can used as pain killer as well as analgesic. It is also used as platelet aggregating agent. The present study focuses on the synthesis, purification, identification and evaluates better drug release with different aspirin formulation (tablet).
Aspirin is non steroidal anti inflammatory drugs as because it is having no steroidal nucleus. It is the acetylated derivative of Benzoic acid. The drug is basically white fine crystalline powdered.
Aspirin is used as analgesic cum anti-inflammatory drug.
It blocks cyclooxygenase (COX) receptor through COX pathway as this receptor is capable to form prostaglandins or PG derivatives. PG derivative is called as pain or inflammation mediator. Therefore by blocking those derivatives, Aspirin can inhibit the cyclooxygenase as well as they can be used for the treatment of pain .
Another one mechanism of the drug is based on their platelet aggregation.
Aspirin can also inhibit the production of thromboxane synthesis through COX pathway.
Thromboxane is important parameter related to platelet as well as coagulation pathway. By blocking thromboxane, platelets can be aggregated. Therefore, Aspirin can be used as blood thinner agent as well as it is used in the treatment of myocardial heart infraction and heart attack.
Aspirin is generally used as long term treatment with solid dosage formulations. Solid dosage forms are basically composed of solid compressed fine particles with different excipients, binders, etc. Solid dosage forms of Aspirin are having improved drug release property into the targeted site. In the category of solid dosage form, Aspirin tablet is usually prepared by weight granulation method. Besides main drug, some other excipients are mixed into it.
Different types of lubricants, glidants, binders, coating agents, polishing agents, coloring agents, flavoring agents, preservatives can be added to the main active drug for enhancement of the formulations consistency [2-4].
Binders are helps to hold the ingredients in a tablet each other and ensure that tablets can be formed with required mechanical strength.
Authors would gratefully thanks to the library department and laboratory technicians of Global College of Pharmaceutical Technology, Nadia, West Bengal, India for successfully completing this research work.
 Hoque I, Chatterjee A, Bhattacharya S, Biswas R, Auddy S and Mondal K; A Review on different types of the Non Steroidal Anti-Inflammatory Drugs (NSAIDs); International Journal of Advanced Multidisciplinary Research; 2016; 3(9): 41-51.
 Singh P, Kumar P and Prasad N; Formulation and Evaluation of Aspirin Tablets by Using Different Lubricants in Combination for better Kinetic Drug Release Study by PCP; Research Journal of Pharmacy and Technology; 2017; 10(9): 2934-2938.
 al Gohary OM, el Din K and el Tahir H; Formulation of aspirin-magaldrate double-layer tablets: in vitro evaluation and cytoprotective activity in rats; Bollettino Chimicopharmaceutics; 1996; 135(7): 421-428.
 Abe T, Yanagihara Y, Uchino T, Oriyama T, Komatsu M and Nakajima K; Evaluation of the pharmaceutical characteristics of various enteric-coated aspirin tablets under different storage conditions; Chemical & Pharmaceutical Bulletin; 2014; 62(7): 617-626.
 Siddiqui AA and Siddiqui S; Experimental Pharmaceutical Chemistry; List of Organic Preparations; CBS Publishers & Distributors Pvt. Ltd.; 2013; 3; 209-211.
 Ubhe TS and Gedam P ; A Brief Overview on Tablet and It’s Types; Journal of Advancement in Pharmacology; 2020; 1(1): 21-31.
 Jariwala DM, Patel HP, Desai CT, Shah SA and Shah DR; A Review on Multiple Compressed Tablets; Journal of pharmaceutical sciences and boiscientific research; 2016; 6(3): 371-379.
 Karim S, Hossain F, Uddin J, Bhuiyan MA and Harun-Or-Rashid M; Formulation and In Vitro Evaluation of Aspirin Sustained Release Tablets Using Hydrophilic Polymers; World Journal of Science and Engineering; 2016; 3(3): 39-45.
 Leesawat P, Laopongpaisan A and Sirithunyalug J; Optimization of Direct Compression Aspirin Tablet Using Statistical Mixture Design; Chiang Mai University Journal of Natural Sciences; 2004; 3(2): 97-112.
 Avbunudiogba JA, Omonyemen E, Torunarigha C and Onah I; Effect of Humidity on the Physical Properties of Aspirin Tablets Produced By Melt Granulation and Slugging Methods; Journal of Pharmacy and Biological Sciences; 2013; 7(5): 20-25.
 Onyekweli AO; Adaptation of Erweka Tablet friabilator for Tap density measurement; West African Journal of Pharmacy; 2000; 14: 74-78.
 Colombo P, Conte U, Caramella C, Geddo M and La Manna A; Disintegrating force as a new formulation parameter; Journal of Pharmaceutical Sciences; 1984; 73(5): 701-705.
 Tawfeek HM, Faisal W and Soliman GM; Enalapril maleate orally disintegrating tablets: Tableting and in vivo evaluation in hypertensive rats; Pharmaceutical Development and Technology; 2017; 23(5): 496-503.
 Voelker M and Hammer M; Dissolution and pharmacokinetics of a novel micronized aspirin formulation; Inflammopharmacology; 2012; 20(4): 225-231.
 Dacic M, Uzunovic A, Kunic A, Pilipovic S and Sapcanin A; UV-VIS Determination of Acetylsalicylic Acid in Aspirin Tablets Using Different Solvents and Conditions; International Conference on Medical and Biological Engineering; 2019; 73: 563-567.